Ecological validity of cognitive fluctuations in dementia with Lewy bodies.

IF 2.6 4区心理学 Q2 CLINICAL NEUROLOGY

Journal of the International Neuropsychological Society Pub Date : 2024-01-01 Epub Date: 2023-04-14 DOI:10.1017/S1355617723000255

Troy A Webber, Sara A Lorkiewicz, Andrew M Kiselica, Steven P Woods

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引用次数: 0

Abstract

Objectives: Cognitive fluctuations are a core clinical feature of dementia with Lewy bodies (DLB), but their contribution to the everyday functioning difficulties evident DLB are not well understood. The current study evaluated whether intraindividual variability across a battery of neurocognitive tests (intraindividual variability-dispersion) and daily cognitive fluctuations as measured by informant report are associated with worse daily functioning in DLB.

Methods: The study sample included 97 participants with consensus-defined DLB from the National Alzheimer's Coordinating Center (NACC). Intraindividual variability-dispersion was measured using the coefficient of variation, which divides the standard deviation of an individual's performance scores across 12 normed neurocognitive indices from the NACC neuropsychological battery by that individual's performance mean. Informants reported on daily cognitive fluctuations using the Mayo Fluctuations Scale (MFS) and on daily functioning using the functional activities questionnaire (FAQ).

Results: Logistic regression identified a large univariate association of intraindividual variability-dispersion and presence of daily cognitive fluctuations on the MFS (Odds Ratio = 73.27, 95% Confidence Interval = 1.38, 3,895.05). Multiple linear regression demonstrated that higher intraindividual variability-dispersion and presence of daily cognitive fluctuations as assessed by the MFS were significantly and independently related to worse daily functioning (FAQ scores).

Conclusions: Among those with DLB, informant-rated daily cognitive fluctuations and cognitive fluctuations measured in the clinic (as indexed by intraindividual variability-dispersion across a battery of tests) were independently associated with poorer everyday functioning. These data demonstrate ecological validity in measures of cognitive fluctuations in DLB.

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路易体痴呆认知波动的生态学有效性。

目的：认知波动是路易体痴呆症（DLB）的一个核心临床特征，但它们对明显的DLB日常功能困难的影响尚不清楚。目前的研究评估了一组神经认知测试中的个体内变异性（个体内变异分散度）和线人报告测量的每日认知波动是否与DLB的日常功能恶化有关。方法：研究样本包括来自国家阿尔茨海默病协调中心（NACC）的97名一致定义的DLB参与者。个体内变异性离散度是使用变异系数来测量的，变异系数将NACC神经心理组中12个标准化神经认知指数中个体表现得分的标准差除以该个体的表现平均值。举报人使用Mayo波动量表（MFS）报告日常认知波动，并使用功能活动问卷（FAQ）报告日常功能。结果：Logistic回归发现个体内变异性分散与MFS上日常认知波动存在较大的单变量关联（比值比=73.27，95%置信区间=1.38，3895.05）多元线性回归表明，MFS评估的较高个体内变异性离散度和每日认知波动的存在与较差的日常功能（FAQ评分）显著且独立相关。结论：在DLB患者中，被举报人评定的每日认知波动和在诊所测量的认知波动（通过一系列测试中的个体内变异性离散度来衡量）与较差的日常功能独立相关。这些数据证明了DLB认知波动测量的生态有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the International Neuropsychological Society 医学-精神病学

CiteScore

5.40

自引率

3.80%

发文量

185

审稿时长

4-8 weeks

期刊介绍： The Journal of the International Neuropsychological Society is the official journal of the International Neuropsychological Society, an organization of over 4,500 international members from a variety of disciplines. The Journal of the International Neuropsychological Society welcomes original, creative, high quality research papers covering all areas of neuropsychology. The focus of articles may be primarily experimental, applied, or clinical. Contributions will broadly reflect the interest of all areas of neuropsychology, including but not limited to: development of cognitive processes, brain-behavior relationships, adult and pediatric neuropsychology, neurobehavioral syndromes (such as aphasia or apraxia), and the interfaces of neuropsychology with related areas such as behavioral neurology, neuropsychiatry, genetics, and cognitive neuroscience. Papers that utilize behavioral, neuroimaging, and electrophysiological measures are appropriate. To assure maximum flexibility and to promote diverse mechanisms of scholarly communication, the following formats are available in addition to a Regular Research Article: Brief Communication is a shorter research article; Rapid Communication is intended for "fast breaking" new work that does not yet justify a full length article and is placed on a fast review track; Case Report is a theoretically important and unique case study; Critical Review and Short Review are thoughtful considerations of topics of importance to neuropsychology and include meta-analyses; Dialogue provides a forum for publishing two distinct positions on controversial issues in a point-counterpoint format; Special Issue and Special Section consist of several articles linked thematically; Letter to the Editor responds to recent articles published in the Journal of the International Neuropsychological Society; and Book Review, which is considered but is no longer solicited.