At the Crossroad of Nucleotide Dynamics and Protein Synthesis in Bacteria.

IF 8 1区 生物学 Q1 MICROBIOLOGY
Microbiology and Molecular Biology Reviews Pub Date : 2023-03-21 Epub Date: 2023-02-28 DOI:10.1128/mmbr.00044-22
Lorenzo Eugenio Leiva, Victor Zegarra, Gert Bange, Michael Ibba
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引用次数: 0

Abstract

Nucleotides are at the heart of the most essential biological processes in the cell, be it as key protagonists in the dogma of molecular biology or by regulating multiple metabolic pathways. The dynamic nature of nucleotides, the cross talk between them, and their constant feedback to and from the cell's metabolic state position them as a hallmark of adaption toward environmental and growth challenges. It has become increasingly clear how the activity of RNA polymerase, the synthesis and maintenance of tRNAs, mRNA translation at all stages, and the biogenesis and assembly of ribosomes are fine-tuned by the pools of intracellular nucleotides. With all aspects composing protein synthesis involved, the ribosome emerges as the molecular hub in which many of these nucleotides encounter each other and regulate the state of the cell. In this review, we aim to highlight intracellular nucleotides in bacteria as dynamic characters permanently cross talking with each other and ultimately regulating protein synthesis at various stages in which the ribosome is mainly the principal character.

在细菌核苷酸动力学和蛋白质合成的十字路口。
核苷酸是细胞中最基本的生物过程的核心,无论是作为分子生物学教条中的关键主角,还是通过调节多种代谢途径。核苷酸的动态性质、核苷酸之间的相互影响以及核苷酸对细胞代谢状态的持续反馈,使核苷酸成为适应环境和生长挑战的标志。人们越来越清楚地认识到,RNA 聚合酶的活性、tRNA 的合成和维持、mRNA 翻译的各个阶段以及核糖体的生物生成和组装都受到细胞内核苷酸池的微调。由于蛋白质合成涉及方方面面,核糖体成为许多核苷酸彼此相遇并调节细胞状态的分子枢纽。在这篇综述中,我们旨在强调细菌中的细胞内核苷酸是动态的角色,它们长期相互交织,最终在不同阶段调节蛋白质合成,而核糖体是其中的主要角色。
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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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