Pyroptosis: A road to next-generation cancer immunotherapy

IF 7.4 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2023-07-01 DOI:10.1016/j.smim.2023.101782

Yiliang Fang , Yaxing Tang , Bo Huang

引用次数: 4

Abstract

The goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8⁺T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse immunosuppression of the tumor microenvironment (TME) but also enhance tumor antigen presentation by dendritic cells, leading to robust antitumor immunity. Exploring nanoparticles and other approaches to spatiotemporally control tumor pyroptosis by regulating gasdermin expression and activation is promising for next-generation immunotherapy.

查看原文本刊更多论文

Pyroptosis：通往下一代癌症免疫疗法的道路

癌症免疫疗法的目标是通过激活抗肿瘤免疫，特别是通过动员肿瘤反应性CD8+T细胞来清除肿瘤细胞。Pyroptosis是由gasdermin（GSDM）介导的程序性裂解细胞死亡，导致细胞抗原、损伤相关分子模式（DAMP）和细胞因子的释放。因此，Pyropotic肿瘤细胞衍生的肿瘤抗原和DAMP不仅可以逆转肿瘤微环境（TME）的免疫抑制，还可以增强树突状细胞对肿瘤抗原的呈递，从而产生强大的抗肿瘤免疫。探索纳米颗粒和其他方法，通过调节gasdermin的表达和激活，时空控制肿瘤焦下垂，有望用于下一代免疫治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.