Comparison of Biological Properties and Clinical Application of Mesenchymal Stem Cells from the Mesoderm and Ectoderm.

IF 3.8 3区医学 Q2 CELL & TISSUE ENGINEERING

Stem Cells International Pub Date : 2023-06-10 eCollection Date: 2023-01-01 DOI:10.1155/2023/4547875

Zhenning Wang, Meng Huang, Yu Zhang, Xiaoxia Jiang, Lulu Xu

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引用次数: 1

Abstract

Since the discovery of mesenchymal stem cells (MSCs) in the 1970s, they have been widely used in the treatment of a variety of diseases because of their wide sources, strong differentiation potential, rapid expansion in vitro, low immunogenicity, and so on. At present, most of the related research is on mesoderm-derived MSCs (M-MSCs) such as bone marrow MSCs and adipose-derived MSCs. As a type of MSC, ectoderm-derived MSCs (E-MSCs) have a stronger potential for self-renewal, multidirectional differentiation, and immunomodulation and have more advantages than M-MSCs in some specific conditions. This paper analyzes the relevant research development of E-MSCs compared with that of M-MSCs; summarizes the extraction, discrimination and culture, biological characteristics, and clinical application of E-MSCs; and discusses the application prospects of E-MSCs. This summary provides a theoretical basis for the better application of MSCs from both ectoderm and mesoderm in the future.

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中胚层与外胚层间充质干细胞生物学特性及临床应用比较。

自20世纪70年代发现间充质干细胞以来，由于其来源广泛、分化潜能强、体外扩增快、免疫原性低等特点，已被广泛应用于多种疾病的治疗。作为一种MSC，外胚层来源的MSC（E-MSCs）具有更强的自我更新、多向分化和免疫调节潜力，在某些特定条件下比M-MSCs更有优势。本文分析了E-MSC与M-MSC的相关研究进展；综述了E-MSCs的提取、鉴别培养、生物学特性及临床应用；并对E-MSC的应用前景进行了探讨。本综述为今后外胚层和中胚层间充质干细胞的更好应用提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cells International CELL & TISSUE ENGINEERING-

CiteScore

8.10

自引率

2.30%

发文量

188

审稿时长

18 weeks

期刊介绍： Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and clinical research, including animal models and clinical trials. Topics covered include, but are not limited to: embryonic stem cells; induced pluripotent stem cells; tissue-specific stem cells; stem cell differentiation; genetics and epigenetics; cancer stem cells; stem cell technologies; ethical, legal, and social issues.