Comparison of Gastric Cancer Risk Classifications Using Conventional and New Pepsinogen Criteria.

IF 2 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Tae Sasakabe, Yuki Obata, Sayo Kawai, Yingsong Lin, Shogo Kikuchi
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引用次数: 2

Abstract

Background: New serum pepsinogen (PG) criteria have been shown to indicate more accurately infection with Helicobacter pylori (H. pylori). We sought to improve risk classification for gastric cancer by adopting the new PG criteria with the addition of an H. pylori antibody test.

Methods: The study participants were 275 patients with gastric cancer and 275 apparently healthy controls from case-control study data. We cross-sectionally compared the results of gastric cancer risk classifications that were based on a combination of the new PG criteria (PG II ≥ 10 ng/mL or PG I/II ≤ 5) and an H. pylori antibody test with those that were based on a combination of the conventional criteria (PG I ≤ 70 ng/mL and PG I/PG II ≤ 3) and an H. pylori antibody test.

Results: Applying the conventional criteria resulted in 89 controls being classified as low risk. Applying the new criteria resulted in 23 controls (bootstrapped 95% confidence intervals [CI]: 14, 32) being additionally classified as high risk. Eight patients with gastric cancer were classified as low risk using the conventional criteria; however, six of these patients were classified as high risk by the new criteria (bootstrapped 95% CI: 2, 11).

Conclusions: Compared with the conventional criteria, the new PG criteria with H. pylori antibody reduced instances of gastric cancer cases being misclassified as low risk. These findings suggest that the new PG criteria may help identify individuals at high risk of developing gastric cancer.

Abstract Image

传统与新型胃蛋白酶原标准胃癌危险分级的比较。
背景:新的血清胃蛋白酶原(PG)标准已被证明更准确地指示幽门螺杆菌(H. pylori)感染。我们试图通过采用新的PG标准并增加幽门螺杆菌抗体测试来改善胃癌的风险分类。方法:从病例对照研究资料中选取275例胃癌患者和275例表面健康对照者作为研究对象。我们横断面比较了基于新PG标准(PG II≥10 ng/mL或PG I/II≤5)和幽门螺杆菌抗体检测相结合的胃癌风险分类结果与基于传统标准(PG I≤70 ng/mL和PG I/PG II≤3)和幽门螺杆菌抗体检测相结合的胃癌风险分类结果。结果:采用常规标准,89例对照者被归为低危。应用新标准导致23个对照(自举95%置信区间[CI]: 14,32)被额外归类为高风险。8例胃癌患者按常规标准归为低危;然而,根据新标准,其中6例患者被分类为高风险(自举95% CI: 2,11)。结论:与常规标准相比,新的带有幽门螺旋杆菌抗体的PG标准减少了胃癌被误判为低危险的病例。这些发现表明,新的PG标准可能有助于识别胃癌高危人群。
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来源期刊
Gastroenterology Research and Practice
Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.40
自引率
0.00%
发文量
91
审稿时长
1 months
期刊介绍: Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.
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