Case Series of Frontal Fibrosing Alopecia and Fibrosing Alopecia in a Pattern Distribution: Is There a Familial Correlation?

IF 1.4 Q3 DERMATOLOGY

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-03-30 DOI:10.1159/000529923

Maria Fernanda Reis Gavazzoni Dias, Amanda Lofeu Cury, Enoi Aparecida Guedes Vilar, Patricia Guimarães Peixoto, Chloe Ekelem

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引用次数: 0

Abstract

Introduction: Frontal Fibrosing Alopecia (FFA) and Fibrosing Alopecia in a Pattern Distribution (FAPD) are two distinct entities of cicatricial pattern hair loss that share histological features of perifollicular lichenoid inflammation associated with concentric fibrosis. Although the pathophysiology of FFA and FAPD are still unknown, recently published reports of familial cases indicate a possible genetic correlation.

Case presentation: We report 6 cases of familial alopecia composed of mothers and daughters: five with FFA and one with FAPD. We describe clinical, trichoscopy and histological correlation in cases of familial alopecia.

Conclusions: These cases of mother and daughter disease association suggest a potential benefit of and role for performing systematic scalp examinations of all first-degree relatives of patients with pattern cicatricial alopecia.

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额部纤维性脱发和花纹分布的纤维性脱发病例系列：是否存在家族相关性？

简介：额部纤维性脱发（FFA）和花斑状纤维性脱发（FAPD）是两种截然不同的卡他性脱发，其共同的组织学特征是毛囊周围苔癣样炎症伴同心纤维化。虽然 FFA 和 FAPD 的病理生理学尚不清楚，但最近发表的家族性病例报告表明，它们可能与遗传有关：我们报告了 6 例由母亲和女儿组成的家族性脱发病例：其中 5 例患有 FFA，1 例患有 FAPD。我们描述了家族性脱发病例的临床、三镜检查和组织学相关性：这些母女疾病关联病例表明，对模式环状脱发患者的所有一级亲属进行系统的头皮检查具有潜在的益处和作用。

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来源期刊

Skin Appendage Disorders DERMATOLOGY-

CiteScore

2.00

自引率

10.00%

发文量