C19-diterpenoid alkaloids from Aconitum refractum var. circinatum

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-09-16 DOI:10.1080/14786419.2023.2223736

引用次数: 0

Abstract

Two unprecedented aconitine-type C19-diterpenoid alkaloids, refractines A–B (1–2), along with 12 known compounds (3–14) were isolated from the roots of Aconitum refractum (Finet et Gagnep.) Hand. -Mazz. Their structures were elucidated based on extensive spectroscopic analyses, including 1D and 2D NMR, IR, and HR-ESI-MS data. All compounds were tested for inhibitory activities against NO production in LPS induced RAW 264.7 macrophages, compounds 10 and 14 had slight inhibited NO production with rate of 29.4% and 22.1% at the concentration of 30 μM, respectively.

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毛乌头中C19二萜生物碱。

从 Aconitum refractum (Finet et Gagnep.) Hand.-Mazz.根据广泛的光谱分析，包括一维和二维核磁共振、红外光谱和 HR-ESI-MS 数据，阐明了这些化合物的结构。测试了所有化合物对 LPS 诱导的 RAW 264.7 巨噬细胞产生 NO 的抑制活性，化合物 10 和 14 对 NO 的产生有轻微的抑制作用，浓度为 30 μM 时的抑制率分别为 29.4% 和 22.1%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.