Antifungal Activity of Efinaconazole Compared with Fluconazole, Itraconazole, and Terbinafine Against Terbinafine- and Itraconazole-Resistant/Susceptible Clinical Isolates of Dermatophytes, Candida, and Molds.

IF 0.5 4区医学 Q4 ORTHOPEDICS

Journal of the American Podiatric Medical Association Pub Date : 2024-09-01 DOI:10.7547/22-132

Ahmed Gamal, Mohammed Elshaer, Lisa Long, Thomas S McCormick, Boni Elewski, Mahmoud A Ghannoum

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引用次数: 0

Abstract

Background: Recently, an increasing number of resistant-to-terbinafine dermatophytosis cases have been reported. Thus, identifying an alternative antifungal agent that possesses broad-spectrum activity, including against resistant strains, is needed.

Methods: We compared the antifungal activity of efinaconazole with that of fluconazole, itraconazole, and terbinafine against clinical isolates of dermatophytes, Candida, and molds using in vitro assays. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of each antifungal agent were quantified and compared. Susceptible and resistant clinical isolates of Trichophyton mentagrophytes (n = 16), Trichophyton rubrum (n = 43), Trichophyton tonsurans (n = 18), Trichophyton violaceum (n = 4), Candida albicans (n = 55), Candida auris (n = 30), Fusarium spp, Scedosporium spp, and Scopulariopsis spp (n = 15 for each) were tested.

Results: Efinaconazole was the most active antifungal agent tested against dermatophytes, with MIC50 and MIC90 (concentrations that inhibited 50% and 90% of strains tested, respectively) values of 0.002 and 0.03 µg/mL, respectively. Fluconazole, itraconazole, and terbinafine showed MIC50 and MIC90 values of 1 and 8 µg/mL, 0.03 and 0.25 µg/mL, and 0.03 and 16 µg/mL, respectively. Against Candida isolates, efinaconazole MIC50 and MIC90 values were 0.016 and 0.25 µg/mL, respectively, whereas fluconazole, itraconazole, and terbinafine had MIC50 and MIC90 values of 1 and 16 µg/mL, 0.25 and 0.5 µg/mL, and 2 and 8 µg/mL, respectively. Against various mold species, efinaconazole MIC values ranged from 0.016 to 2 µg/mL versus 0.5 to greater than 64 µg/mL for the comparators.

Conclusions: Efinaconazole showed superior potent activity against a broad panel of susceptible and resistant dermatophyte, Candida, and mold isolates.

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艾芬康唑与氟康唑、伊曲康唑和特比萘芬对耐/易感特比萘芬和伊曲康唑的皮癣菌、念珠菌和霉菌临床分离株的抗真菌活性比较。

背景：最近，对特比萘芬产生耐药性的皮癣病病例不断增加。因此，需要找到一种具有广谱抗真菌活性（包括抗耐药菌株）的替代抗真菌药物：方法：我们使用体外试验比较了依芬康唑与氟康唑、伊曲康唑和特比萘芬对皮真菌、念珠菌和霉菌临床分离株的抗真菌活性。对每种抗真菌剂的最低抑菌浓度（MIC）和最低杀菌浓度（MFC）进行了量化和比较。对敏感和耐药的临床分离株进行了测试，包括脑毛癣菌（n = 16）、红毛癣菌（n = 43）、扁桃体毛癣菌（n = 18）、暴毛癣菌（n = 4）、白色念珠菌（n = 55）、白色念珠菌（n = 30）、镰刀菌属（Fusarium spp）、Scedosporium spp 和 Scopulariopsis spp（各 n = 15）：埃芬康唑是对皮癣菌最有效的抗真菌剂，其 MIC50 和 MIC90（分别抑制 50%和 90%受试菌株的浓度）值分别为 0.002 和 0.03 µg/mL。氟康唑、伊曲康唑和特比萘芬的 MIC50 和 MIC90 值分别为 1 和 8 微克/毫升、0.03 和 0.25 微克/毫升以及 0.03 和 16 微克/毫升。对于念珠菌分离物，依芬康唑的 MIC50 和 MIC90 值分别为 0.016 和 0.25 µg/mL ，而氟康唑、伊曲康唑和特比萘芬的 MIC50 和 MIC90 值分别为 1 和 16 µg/mL、0.25 和 0.5 µg/mL 以及 2 和 8 µg/mL。对于各种霉菌，依芬康唑的 MIC 值介于 0.016 至 2 µg/mL 之间，而对比药的 MIC 值介于 0.5 至大于 64 µg/mL 之间：结论：依非那唑对多种易感和耐药的皮癣菌、念珠菌和霉菌分离物显示出卓越的强效活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Podiatric Medical Association 医学-整形外科

CiteScore

1.10

自引率

0.00%

发文量

128

审稿时长

6-12 weeks

期刊介绍： The Journal of the American Podiatric Medical Association, the official journal of the Association, is the oldest and most frequently cited peer-reviewed journal in the profession of foot and ankle medicine. Founded in 1907 and appearing 6 times per year, it publishes research studies, case reports, literature reviews, special communications, clinical correspondence, letters to the editor, book reviews, and various other types of submissions. The Journal is included in major indexing and abstracting services for biomedical literature.