David A Agard, Gregory R Bowman, William DeGrado, Nikolay V Dokholyan, Huan-Xiang Zhou
{"title":"Solution of the protein structure prediction problem at last: crucial innovations and next frontiers.","authors":"David A Agard, Gregory R Bowman, William DeGrado, Nikolay V Dokholyan, Huan-Xiang Zhou","doi":"10.12703/r-01-0000020","DOIUrl":null,"url":null,"abstract":"<p><p>The protein structure prediction problem is solved, at last, thanks in large part to the use of artificial intelligence. The structures predicted by AlphaFold and RoseTTAFold are becoming the requisite starting point for many protein scientists. New frontiers, such as the conformational sampling of intrinsically disordered proteins, are emerging.</p>","PeriodicalId":73016,"journal":{"name":"Faculty reviews","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815721/pdf/facrev-11-38.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Faculty reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12703/r-01-0000020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The protein structure prediction problem is solved, at last, thanks in large part to the use of artificial intelligence. The structures predicted by AlphaFold and RoseTTAFold are becoming the requisite starting point for many protein scientists. New frontiers, such as the conformational sampling of intrinsically disordered proteins, are emerging.
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