Homocysteine, Vitamins B6, B12, and Folate and the Risk of Ischemic and Hemorrhagic Stroke: A Case-control Study from Northeast India.

IF 1.8 Q4 NEUROSCIENCES

Annals of Neurosciences Pub Date : 2023-01-01 DOI:10.1177/09727531221124425

Manash Ghose, Madhumita Das, Rupjyoti Das, Amit Ranjan Barua, Prasenjit Deka, Aparajita Barman, Vivekananda Lahan, Dhruba Jyoti Choudhury, Jai Prakash Sharma, Manik Mathur, Nomal Chandra Borah, Nupur Choudhury, Ananya Barman

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引用次数: 1

Abstract

Background: Stroke is a major leading global health complication. Identification and management of risk factors associated with stroke can help in prior detection, prevention, and improvement in patient care.

Purpose: To investigate the prevalence of hyperhomocysteinemia (HHcy) and Vitamins B6, B12, and folate deficiency in stroke patients and also to assess other risk factors associated with ischemic and hemorrhagic stroke.

Methods: Detail history of all the subjects in the study including history of hypertension, anemia, fasting glucose, carotid artery thickness, smoking, alcohol, and dietary intake was recorded. Standard assays for homocysteine (Hcy), Vitamins B6, B12, and folate estimation were done. Lipid and renal profile tests were also performed. The prevalence and odds of having HHcy, Vitamins B6, B12, and folate deficiency, and other risk factors in ischemic and hemorrhagic stroke patients were evaluated. Student's t-tests and chi-square tests were done for statistical validation of the data.

Results: Prevalence of HHcy and Vitamins B6, B12, and folate deficiency was not observed in ischemic cases. HHcy and folate deficiency was found to be prevalent in hemorrhagic stroke patients. The odds that a person with HHcy and folate deficiency has hemorrhagic stroke was found to be significantly high.

Conclusion: In our study, high Hcy and low folate levels emerged as risk factors for hemorrhagic stroke.

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同型半胱氨酸、维生素B6、B12和叶酸与缺血性和出血性中风的风险:来自印度东北部的病例对照研究

背景:脑卒中是全球主要的健康并发症。识别和管理与中风相关的危险因素有助于预先发现、预防和改善患者护理。目的:调查脑卒中患者高同型半胱氨酸血症(HHcy)、维生素B6、B12和叶酸缺乏症的患病率，并评估与缺血性和出血性脑卒中相关的其他危险因素。方法:详细记录所有研究对象的病史，包括高血压、贫血、空腹血糖、颈动脉厚度、吸烟、饮酒、饮食摄入等。进行了同型半胱氨酸(Hcy)、维生素B6、B12和叶酸的标准测定。还进行了血脂和肾脏检查。评估缺血性和出血性脑卒中患者HHcy、维生素B6、B12和叶酸缺乏症的患病率和几率，以及其他危险因素。采用学生t检验和卡方检验对数据进行统计验证。结果:在缺血性病例中未观察到HHcy、维生素B6、B12和叶酸缺乏的患病率。出血性中风患者普遍存在HHcy和叶酸缺乏症。患有HHcy和叶酸缺乏症的人患出血性中风的几率非常高。结论:在我们的研究中，高Hcy和低叶酸水平是出血性中风的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Neurosciences NEUROSCIENCES-

CiteScore

2.40

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0.00%

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