Epigenetics of neurological diseases.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Ozasvi R Shanker, Sonali Kumar, Aparna Banerjee Dixit, Jyotirmoy Banerjee, Manjari Tripathi, P Sarat Chandra
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引用次数: 0

Abstract

Higher-order DNA structure and gene expression are governed by epigenetic processes like DNA methylation and histone modifications. Abnormal epigenetic mechanisms are known to contribute to the emergence of numerous diseases, including cancer. Historically, the chromatin abnormalities were only considered to be limited to discrete DNA sequences and were thought to be associated with rare genetic syndrome however, recent discoveries have pointed to genome-wide level changes in the epigenetic machinery which has contributed to a better knowledge of the mechanisms underlying developmental and degenerative neuronal problems associated with diseases such as Parkinson's disease, Huntington's disease, Epilepsy, Multiple sclerosis, etc. In the given chapter we describe the epigenetic alterations seen in various neurological disorders and further discuss the influence of these epigenetic changes on developing novel therapies.

神经系统疾病的表观遗传学。
高阶DNA结构和基因表达受表观遗传过程如DNA甲基化和组蛋白修饰控制。已知异常的表观遗传机制有助于许多疾病的出现,包括癌症。从历史上看,染色质异常只被认为局限于离散的DNA序列,并且被认为与罕见的遗传综合征有关。然而,最近的发现指出了表观遗传机制的全基因组水平变化,这有助于更好地了解与帕金森病、亨廷顿病、癫痫、多发性硬化症等疾病相关的发育和退行性神经元问题的潜在机制。在给定的章节中,我们描述了在各种神经系统疾病中看到的表观遗传改变,并进一步讨论了这些表观遗传变化对开发新疗法的影响。
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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