The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease.

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in lipidology Pub Date : 2023-02-01 DOI:10.1097/MOL.0000000000000857

Marie Winther-Sørensen, Jens J Holst, Nicolai J Wewer Albrechtsen

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引用次数: 0

Abstract

Purpose of review: Glucagon increases hepatic glucose production and in patients with metabolic diseases, glucagon secretion is increased contributing to diabetic hyperglycemia. This review explores the role of amino acids and lipids in the regulation of glucagon secretion and how it may be disturbed in metabolic diseases such as obesity and metabolic associated fatty liver disease (MAFLD).

Recent findings: Human and animal studies have shown that MAFLD is associated with glucagon resistance towards amino acid catabolism, resulting in elevated plasma levels of amino acids. A recent clinical study showed that MAFLD is also associated with glucagon resistance towards lipid metabolism. In contrast, MAFLD may not decrease hepatic sensitivity to the stimulatory effects of glucagon on glucose production.

Summary: Elevated plasma levels of amino acids and lipids associated with MAFLD may cause diabetogenic hyperglucagonemia. MAFLD and glucagon resistance may therefore be causally linked to hyperglycemia and the development of type 2 diabetes.

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葡萄糖、氨基酸和脂质与α细胞分泌之间的反馈循环及其在代谢性脂肪肝中的作用。

综述目的:胰高血糖素增加肝脏葡萄糖生成，在代谢性疾病患者中，胰高血糖素分泌增加导致糖尿病高血糖。这篇综述探讨了氨基酸和脂质在调节胰高血糖素分泌中的作用，以及它如何在代谢性疾病如肥胖和代谢性脂肪性肝病(MAFLD)中受到干扰。最新发现:人类和动物研究表明，MAFLD与胰高血糖素对氨基酸分解代谢的抵抗有关，导致血浆氨基酸水平升高。最近的一项临床研究表明，MAFLD也与胰高血糖素对脂质代谢的抵抗有关。相反，MAFLD可能不会降低肝脏对胰高血糖素对葡萄糖产生的刺激作用的敏感性。总结:与MAFLD相关的血浆氨基酸和脂质水平升高可能导致糖尿病性高胰高血糖素血症。因此，MAFLD和胰高血糖素抵抗可能与高血糖和2型糖尿病的发展有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.