Genetics of adnexal tumors: An update

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2023-09-01 DOI:10.1016/j.annder.2023.03.003

T. Kervarrec , P. Sohier , D. Pissaloux , A. de la Fouchardiere , B. Cribier , M. Battistella , N. Macagno

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引用次数: 1

Abstract

Cutaneous adnexal tumors form a vast heterogeneous group that include frequent entities that are mostly benign, as well as rare tumors that are occasionally malignant. In contrast to cutaneous tumors arising from the interfollicular epidermis that develop as a result of accumulation of UV-induced DNA damage (basal cell carcinoma, squamous cell carcinoma), the oncogenesis of adnexal tumors is related to a broad spectrum of genetic mechanisms (e.g., point mutation, fusion genes, viral integration, etc.). In this setting, specific and recurrent genetic alterations have been progressively reported, and these allow better classification of these entities. For certain of them, immunohistochemical tools are now available, enabling precise integrated histological and molecular diagnosis since certain entities are linked to well-defined alterations. In this context, we aim in this review to summarize the main molecular tools currently available for the classification of adnexal tumors.

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附件肿瘤遗传学：最新进展。

皮肤附件肿瘤形成了一个庞大的异质性群体，包括常见的良性实体，以及偶尔恶性的罕见肿瘤。与因紫外线诱导的DNA损伤积累而形成的毛囊间表皮皮肤肿瘤（基底细胞癌、鳞状细胞癌）不同，附件肿瘤的发生与广泛的遗传机制有关（如点突变、融合基因、病毒整合等），已经逐渐报道了特定的和反复发生的基因改变，这些改变可以更好地对这些实体进行分类。对于其中的某些实体，现在可以使用免疫组织化学工具，实现精确的组织学和分子综合诊断，因为某些实体与明确的改变有关。在这方面，我们的目的是在这篇综述中总结目前可用于附件肿瘤分类的主要分子工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567