Role of the Renin-Angiotensin System Components in Renal Cell Carcinoma: A Literature Review.

IF 2.5 2区医学 Q2 UROLOGY & NEPHROLOGY

Current Urology Reports Pub Date : 2023-07-01 DOI:10.1007/s11934-023-01160-x

Thiago Camelo Mourão, Stephania Martins Bezerra, Victor Espinheira Santos, Eder Silveira Brazão, Walter Henriques da Costa, Stênio de Cássio Zequi

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Abstract

Purpose of review: The physiological aspects of renin-angiotensin system (RAS) components are described in this review. Additionally, we present the main results of studies that could indicate an association between alterations in these components and cancer, particularly renal cell carcinoma (RCC).

Recent findings: The RAS undergoes a series of homeostatic and modulatory processes that extend to hypertrophy, hyperplasia, fibrosis, and remodeling, as well as angiogenesis, pro-inflammatory responses, cell differentiation, stem cell programming, and hematopoiesis. The link between cancer-related inflammation and RAS signaling converge in the response to tumor hypoxia and oxidative stress mechanisms, particularly with the angiotensin type 1 receptor leading to activation of transcription factors such as nuclear factor κB (NF-κB), as well as members of the signal transducer and activation of transcription (STAT) family and HIF1⍺. Dysregulation of the physiological actions of RAS in the microenvironment of inflammation and angiogenesis promotes tumor cell growth.

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肾素-血管紧张素系统成分在肾细胞癌中的作用:文献综述。

综述目的:本文对肾素-血管紧张素系统(RAS)成分的生理方面进行了综述。此外，我们提出的主要研究结果可能表明这些成分的改变与癌症，特别是肾细胞癌(RCC)之间的关联。最近的研究发现:RAS经历了一系列的稳态和调节过程，这些过程延伸到肥大、增生、纤维化和重塑，以及血管生成、促炎反应、细胞分化、干细胞编程和造血。癌症相关炎症和RAS信号之间的联系汇聚在对肿瘤缺氧和氧化应激机制的反应中，特别是血管紧张素1型受体导致转录因子的激活，如核因子κB (NF-κB)，以及信号换能器和转录激活(STAT)家族成员和HIF1。RAS在炎症和血管生成微环境中的生理行为失调促进肿瘤细胞生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Urology Reports UROLOGY & NEPHROLOGY-

CiteScore

4.60

自引率

3.80%

发文量

期刊介绍： This journal intends to review the most important, recently published findings in the field of urology. By providing clear, insightful, balanced contributions by international experts, the journal elucidates current and emerging approaches to the care and prevention of urologic diseases and conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as benign prostatic hyperplasia, erectile dysfunction, female urology, and kidney disease. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.