Controversies in anesthesia-induced developmental neurotoxicity

IF 2.8 3区 医学 Q1 ANESTHESIOLOGY
Nemanja Useinovic (Postdoctoral Fellow) , Vesna Jevtovic-Todorovic (Professor and Chair)
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引用次数: 3

Abstract

Advances in the field of pediatric anesthesiology have enabled the performance of complex and life-saving procedures with minimal patient discomfort. However, preclinical studies over the past two decades have been reporting substantial neurotoxic potential of general anesthetics in young brain, thus challenging the safety of these agents in pediatric anesthesiology practice. Notwithstanding the overwhelming preclinical evidence, the translatability of these findings has proven inconsistent in human observational studies. The significant degree of anxiety and apprehension surrounding the uncertainty of long-term developmental outcomes following early exposure to anesthesia has prompted numerous studies around the world to investigate the putative mechanisms and translatability of preclinical findings regarding anesthesia-induced developmental neurotoxicity. Guided by the vast preclinical evidence, we aim to highlight relevant human findings presented in the currently available clinical literature.

麻醉诱导发育神经毒性的争议
儿科麻醉学领域的进步使复杂的挽救生命的手术能够在最小的患者不适的情况下进行。然而,过去二十年的临床前研究报告称,全身麻醉剂在年轻大脑中具有巨大的神经毒性潜力,因此对这些药物在儿科麻醉学实践中的安全性提出了挑战。尽管有压倒性的临床前证据,但在人类观察性研究中,这些发现的可翻译性已被证明是不一致的。早期暴露于麻醉后,人们对长期发育结果的不确定性感到焦虑和担忧,这促使世界各地的许多研究调查了麻醉诱导的发育神经毒性的临床前发现的假定机制和可翻译性。在大量临床前证据的指导下,我们旨在强调目前可用的临床文献中提出的相关人类发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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