Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines.

IF 2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Bing Zhang, Wenyun Zhang, Jianfang Luo, Jian He, Xiaomin Zheng, Siyang Zhu, Baoshan Rong, Yong Ai, Lanyue Zhang, Tinggang He
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Abstract

Oleanolic acid (OA) is a pentacyclic triterpenoid with favourable physiological activity. It is widely distributed in more than 200 species of plants. OA has garnered significant interest because of its potential biological activities, such as antioxidant, bacteriostatic, and hair growth-promoting effects. To study the effect of OA on hair growth and related mechanisms, we investigated hair growth in mice with testosterone-induced androgenetic alopecia (AGA) that were treated with three different concentrations of OA. The antioxidant, bacteriostatic, and cytotoxic effects of OA were evaluated. We found that mice with testosterone-induced AGA treated with 1% or 0.5% OA showed significantly enhanced hair growth and increased vascular endothelial growth factor/glyceraldehyde-3-phosphate dehydrogenase ratio and levels of fibroblast growth factor receptor and insulin-like growth factor 1. Using an immunofluorescence staining assay, we demonstrated that β-catenin, a key Wnt signalling transducer, was highly expressed in the OA-treated groups. These results suggest that OA may promote hair growth by stimulating hair matrix cell proliferation via the Wnt/β-catenin pathway and lowering the levels of tumour necrosis factor-alpha, and transforming growth factor-beta 1, dihydrotestosterone, and 5α-reductase.

齐墩果酸通过调节炎症细胞因子对小鼠背侧皮肤毛发生长的影响。
齐墩果酸(OA)是一种具有良好生理活性的五环三萜化合物。它广泛分布于200多种植物中。由于其潜在的生物活性,如抗氧化、抑菌和促进头发生长的作用,OA获得了极大的兴趣。为了研究OA对毛发生长的影响及其相关机制,我们研究了三种不同浓度OA对睾丸激素诱导的雄激素性脱发(AGA)小鼠毛发生长的影响。评估了OA的抗氧化、抑菌和细胞毒作用。我们发现,1%或0.5% OA处理的睾丸激素诱导AGA小鼠的毛发生长显著增强,血管内皮生长因子/甘油醛-3-磷酸脱氢酶比值增加,成纤维细胞生长因子受体和胰岛素样生长因子1水平增加。通过免疫荧光染色分析,我们发现β-catenin(一种关键的Wnt信号转导因子)在果酸处理组中高度表达。上述结果提示OA可能通过Wnt/β-catenin通路刺激毛发基质细胞增殖,降低肿瘤坏死因子- α、转化生长因子- β 1、双氢睾酮和5α-还原酶水平,从而促进毛发生长。
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来源期刊
Journal of applied biomedicine
Journal of applied biomedicine PHARMACOLOGY & PHARMACY-
CiteScore
2.40
自引率
7.70%
发文量
13
审稿时长
>12 weeks
期刊介绍: Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.
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