Angiotensin-converting enzyme insertion/deletion gene polymorphism and Henoch-Schonlein purpura nephritis risk in children: a meta-analysis.

IF 0.7 4区医学 Q4 PATHOLOGY

Polish Journal of Pathology Pub Date : 2023-01-01 DOI:10.5114/pjp.2023.127014

Pan Yan, Song Xu

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引用次数: 0

Abstract

It has been demonstrated in many studies that angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is related to Henoch-Schonlein purpura nephritis (HSPN) risk in children. However, this conclusion remains controversial. In this study, we systemically retrieved relevant studies in electronic databases such as PUBMED, CNKI, and EMBASE followed by calculation of odds ratios (OR) with 95% confidence intervals (CI). In addition, meta-package in STATA version 12.0 was used. Angiotensin-converting enzyme I/D polymorphism was related to HSPN susceptibility in children (D vs. I: OR 1.47, 95% CI: 1.13-1.93; DD vs. II: OR 2.29, 95% CI: 1.29-4.07; DI vs. II: OR 1.10, 95% CI: 0.82-1.48; dominant model: OR 1.44, 95% CI: 1.09-1.89; recessive model: OR 2.26, 95% CI: 1.67-3.06). In addition, subgroup analysis stratified according to ethnicity indicated a significant relationship between this polymorphism and HSPN susceptibility among Asians and Caucasians. The data extracted from HaploReg indicated that ACE I/D polymorphism was not in linkage disequilibrium with other variants in the ACE gene. The research shows that ACE I/D polymorphism is related to HSPN susceptibility in children.

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血管紧张素转换酶插入/缺失基因多态性与儿童紫癜性肾炎风险:一项荟萃分析

许多研究表明，血管紧张素转换酶(ACE)插入/缺失(I/D)多态性与儿童紫癜性肾炎(HSPN)风险相关。然而，这一结论仍然存在争议。在本研究中，我们系统地检索了PUBMED、CNKI和EMBASE等电子数据库中的相关研究，并计算了95%置信区间(CI)的比值比(OR)。使用STATA 12.0版本的meta-package。血管紧张素转换酶I/D多态性与儿童HSPN易感性相关(D vs. I: OR: 1.47, 95% CI: 1.13-1.93;DD vs. II: OR 2.29, 95% CI: 1.29-4.07;DI vs. II: OR 1.10, 95% CI: 0.82-1.48;优势模型:OR 1.44, 95% CI: 1.09-1.89;隐性模型:OR 2.26, 95% CI: 1.67-3.06)。此外，根据种族分层的亚组分析表明，这种多态性与亚洲人和高加索人的HSPN易感性之间存在显著关系。从HaploReg中提取的数据表明，ACE I/D多态性与ACE基因的其他变异不存在连锁不平衡。研究表明，ACE I/D多态性与儿童HSPN易感性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polish Journal of Pathology PATHOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Polish Journal of Pathology is an official magazine of the Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology. For the last 18 years of its presence on the market it has published more than 360 original papers and scientific reports, often quoted in reviewed foreign magazines. A new extended Scientific Board of the quarterly magazine comprises people with recognised achievements in pathomorphology and biology, including molecular biology and cytogenetics, as well as clinical oncology. Polish scientists who are working abroad and are international authorities have also been invited. Apart from presenting scientific reports, the magazine will also play a didactic and training role.