The Clinical Value of Rodent Models in Understanding Preeclampsia Development and Progression.

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Sapna Ramdin, Sooraj Baijnath, Thajasvarie Naicker, Nalini Govender
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引用次数: 0

Abstract

Purpose of review: Preeclampsia (PE) is a leading global cause of maternal and fetal morbidity and mortality. The heterogeneity of this disorder contributes to its elusive etiology. Due to the ethical constraints surrounding human studies, animal models provide a suitable alternative for investigation into PE pathogenesis and novel therapeutic strategies. The purpose of this review is to compare and contrast the various rodent models used to study PE, in order to demonstrate their value in investigating and identifying different characteristics of this disorder.

Recent findings: Several approaches have been employed to create an appropriate animal model of PE, including surgical, genetic manipulation, and pharmacological methods in an attempt to mimic the maternal syndrome. Despite the absence of a model to completely model PE, these models have provided valuable information concerning various aspects of PE pathogenesis and novel therapeutic strategies and have led to the discovery of potential predictive markers of PE. Rodent and murine models have contributed significantly to the study of the pathology associated with specific aspects of the disorder. As a single fully encompassing animal model of PE remains absent, the use of a combination of models has potential value in understanding its etiology as well as in new treatment and management strategies.

Abstract Image

啮齿动物模型在了解子痫前期发生和进展中的临床价值。
综述目的:先兆子痫(PE)是全球孕产妇和胎儿发病率和死亡率的主要原因。这种疾病的异质性导致其难以捉摸的病因。由于人类研究的伦理限制,动物模型为研究PE的发病机制和新的治疗策略提供了合适的选择。本综述的目的是比较和对比用于研究PE的各种啮齿动物模型,以证明它们在调查和识别这种疾病的不同特征方面的价值。最近的发现:已经采用了几种方法来创建适当的PE动物模型,包括手术,遗传操作和药理学方法,试图模仿母体综合征。尽管没有一个模型可以完全模拟PE,但这些模型为PE的发病机制和新的治疗策略的各个方面提供了有价值的信息,并导致PE潜在预测标志物的发现。啮齿动物和小鼠模型对与该疾病特定方面相关的病理学研究做出了重大贡献。由于缺乏一种完整的PE动物模型,因此使用多种模型的组合对于了解其病因以及新的治疗和管理策略具有潜在的价值。
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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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