What is new in pharmacological treatment for osteoarthritis?

IF 4.5 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI:10.1016/j.berh.2023.101841

Halise Hande Gezer , Andrew Ostor

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Abstract

Osteoarthritis (OA) is a degenerative joint disease in which structural changes of hyaline articular cartilage, subchondral bone, ligaments, capsule, synovium, muscles, and periarticular changes are involved. The knee is the most commonly affected joint, followed by the hand, hip, spine, and feet. Different pathological mechanisms are at play in each of these various involvement sites. Although systemic inflammation is more prominent in hand OA, knee and hip OA have been associated with excessive joint load and injury. As OA has varied phenotypes and the primarily affected tissues differ, treatment options must be tailored accordingly. In recent years, ongoing efforts have been made to develop disease-modifying options that halt or slow disease progression. Many are still in clinical trials, and as insights into the pathogenesis of OA evolve, novel therapeutic strategies will be developed. In this chapter, we provide an overview of the novel and emerging strategies in the management of OA.

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骨关节炎的药物治疗有何新进展？

骨关节炎（OA）是一种退行性关节疾病，涉及透明关节软骨、软骨下骨、韧带、关节囊、滑膜、肌肉和关节周围结构的改变。膝关节是最常受影响的关节，其次是手、髋、脊柱和足。受累部位不同，病理机制也不同。虽然全身性炎症在手部 OA 中更为突出，但膝关节和髋关节 OA 与关节负荷过重和损伤有关。由于 OA 具有不同的表型，主要受累组织也各不相同，因此必须相应地制定治疗方案。近年来，人们一直在努力开发能够阻止或延缓疾病进展的治疗方案。其中许多方案仍在临床试验中，随着对 OA 发病机理认识的不断深入，新的治疗策略也将应运而生。在本章中，我们将概述治疗 OA 的新策略和新兴策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.