Air Pollution-Related Neurotoxicity Across the Life Span.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Deborah A Cory-Slechta, Alyssa Merrill, Marissa Sobolewski
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引用次数: 0

Abstract

Air pollution is a complex mixture of gases and particulate matter, with adsorbed organic and inorganic contaminants, to which exposure is lifelong. Epidemiological studies increasingly associate air pollution with multiple neurodevelopmental disorders and neurodegenerative diseases, findings supported by experimental animal models. This breadth of neurotoxicity across these central nervous system diseases and disorders likely reflects shared vulnerability of their inflammatory and oxidative stress-based mechanisms and a corresponding ability to produce brain metal dyshomeo-stasis. Future research to define the responsible contaminants of air pollution underlying this neurotoxicity is critical to understanding mechanisms of these diseases and disorders and protecting public health.

生命周期中与空气污染相关的神经毒性。
空气污染是一种复杂的气体和颗粒物混合物,其中吸附了有机和无机污染物,人们终生都会受到空气污染的影响。流行病学研究越来越多地将空气污染与多种神经发育障碍和神经退行性疾病联系起来,实验动物模型也支持这些研究结果。这些中枢神经系统疾病和失调症的神经毒性范围之广,很可能反映了它们基于炎症和氧化应激机制的共同脆弱性,以及产生大脑金属失衡的相应能力。未来研究确定这种神经毒性背后的空气污染污染物,对于了解这些疾病和失调的机制以及保护公众健康至关重要。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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