Two new norcassane-type diterpenoids from Mezonevron sinense Hemsl

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-09-16 DOI:10.1080/14786419.2023.2219821

引用次数: 0

Abstract

Two new norcassane-type diterpenoids, named 6β-hydroxy-bisnorcass-13-en-12-one (1) and 6β-hydroxy-bisnorcassan-12-one (2), were isolated from the seeds of Mezonevron sinense Hemsl. The structures of compounds 1-2 were determined by extensive spectroscopic analysis. Two compounds exhibited immunosuppressive activity with the IC₅₀ values of 19.35 ± 0.87 μM and 18.69 ± 0.88 μM in the ConA induced T cell model and 65.04 ± 0.83 μM and 48.06 ± 0.76 μM in LPS induced B cell model, respectively.

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从 Mezonevron sinense Hemsl.

从 Mezonevron sinense Hemsl 的种子中分离出了两种新的去甲山嵛烷型二萜类化合物，分别命名为 6β-hydroxy-bisnorcass-13-en-12-one (1) 和 6β-hydroxy-bisnorcassan-12-one (2)。通过大量光谱分析确定了 1-2 号化合物的结构。两个化合物具有免疫抑制活性，在 ConA 诱导的 T 细胞模型中的 IC50 值分别为 19.35 ± 0.87 μM 和 18.69 ± 0.88 μM，在 LPS 诱导的 B 细胞模型中的 IC50 值分别为 65.04 ± 0.83 μM 和 48.06 ± 0.76 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.