Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar.

IF 0.6 Q4 ENDOCRINOLOGY & METABOLISM

Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2023-01-01 DOI:10.15605/jafes.037.S2

Sagawah Phu, Aye Thida, Kyu Kyu Maung, Tet Tun Chit

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引用次数: 1

Abstract

Objectives: To investigate the association between the single nucleotide polymorphism (SNP) rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes mellitus (T2DM) and to examine the impact of this variant on pancreatic beta-cell function in the Myanmar population.

Methodology: A case-control study was undertaken in 100 subjects with T2DM and 113 controls. The SNP rs7903146 was genotyped using the allele-specific polymerase chain reaction method. Plasma glucose and serum insulin levels were determined using the enzymatic colorimetric method and ELISA respectively. Beta-cell function was calculated by the HOMA-β formula.

Results: The frequencies of carrier genotypes (CT and TT) were higher in subjects with T2DM than in controls. The minor T alleles of rs7903146 were found to statistically increase type 2 diabetes risk than the C allele with an allelic odds ratio of 2.07 (95% CI 1.39-3.09, p=0.0004). The mean HOMA-β level of the group with non-carrier genotype (CC) was significantly higher than that of the groups with carrier genotypes (CT and TT) in subjects with T2DM and controls with a p-value of 0.0003 and less than 0.0001, respectively.

Conclusion: The rs7903146 variant of the TCF7L2 gene was found to be associated with T2DM and low β-cell function among Myanmar subjects.

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缅甸2型糖尿病患者转录因子7样2基因rs7903146位点单核苷酸多态性

目的:探讨转录因子7-样2 (TCF7L2)基因单核苷酸多态性(SNP) rs7903146与2型糖尿病(T2DM)之间的关系，并研究该变异对缅甸人群胰腺β细胞功能的影响。方法:对100例T2DM患者和113例对照组进行病例对照研究。采用等位基因特异性聚合酶链反应法对SNP rs7903146进行基因分型。分别用酶比色法和酶联免疫吸附试验测定血浆葡萄糖和血清胰岛素水平。β细胞功能通过HOMA-β公式计算。结果:T2DM患者携带基因型(CT和TT)的频率高于对照组。rs7903146的次要T等位基因比C等位基因增加2型糖尿病的风险，等位基因优势比为2.07 (95% CI 1.39 ~ 3.09, p=0.0004)。非携带者基因型(CC)组的HOMA-β水平显著高于T2DM患者和对照组的携带者基因型(CT和TT)组，p值分别为0.0003和< 0.0001。结论:发现TCF7L2基因rs7903146变异与缅甸人T2DM和β细胞功能低下有关。

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来源期刊

Journal of the ASEAN Federation of Endocrine Societies ENDOCRINOLOGY & METABOLISM-

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The Journal of the ASEAN Federation of Endocrine Societies (JAFES) is an OPEN ACCESS, internationally peer-reviewed, English language, medical and health science journal that is published in print two times a year by the ASEAN Federation of Endocrine Societies. It shall serve as the endocrine window between the ASEAN region and the world, featuring original papers and publishing key findings from specialists and experts of endocrinology.