Comparing Recovery from Desflurane and Sevoflurane in Patients with Different Body Fat Percentages: A Randomized Controlled Trial.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2024-01-01 DOI:10.2174/1567201820666230328115354

Silu Cao, Huijuan Wang, Lijun Tang, Guanghui An

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引用次数: 0

Abstract

Introduction: Increased body fat may influence the partition coefficients of inhaled anesthetics. We compared patient responses to desflurane and sevoflurane anesthesia, as measured by a quicker recovery and fewer complications, in patients with higher body fat percentages, not only obese people.

Methods: This study included 120 patients. Participants were stratified into low or high body fat percentages groups using bioelectrical impedance analysis and were randomized 1:1 to receive desflurane or sevoflurane as an inhaled anesthetic, recorded as Low-Desflurane, Low-Sevoflurane, High- Desflurane, and High-Sevoflurane. Recovery time, Riker sedation-agitation scale scores, and complications were recorded over 1 hour in the post-anesthesia care unit.

Results: A total of 106 patients were analyzed. There were no significant differences in the overall recovery time between the patient subgroups with higher and lower body fat percentages; in addition, there were no significant differences in the incidence of nausea, vomiting,dizziness, or headache (all p>0.05). However, the incidence of agitation emergence in the HighSevoflurane subgroup was significantly higher compared to the High-Desflurane subgroup (33.3% vs.7.41%; p = 0.043).

Conclusion: In conclusion, for patients with a lower body fat percentage, both desflurane and sevoflurane can provide good and fast recovery; for patients with a higher body fat percentage,desflurane may provide better recovery with a lower incidence of agitation emergence compared to sevoflurane.

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比较地氟醚和七氟醚在不同体脂百分比患者中的恢复:一项随机对照试验。

简介:体脂增加可能影响吸入麻醉剂的分配系数。我们比较了患者对地氟醚和七氟醚麻醉的反应，通过更快的恢复和更少的并发症来衡量，这些患者体脂率较高，而不仅仅是肥胖患者。方法:本研究纳入120例患者。使用生物电阻抗分析将参与者分为体脂百分比低或高的组，并按1:1的比例随机分配接受地氟烷或七氟烷作为吸入麻醉剂，记录为低地氟烷、低七氟烷、高地氟烷和高七氟烷。在麻醉后护理单元记录恢复时间、Riker镇静-躁动量表评分和并发症超过1小时。结果:共分析106例患者。体脂率较高和较低的患者亚组之间的总体恢复时间无显著差异;此外，两组恶心、呕吐、头晕、头痛的发生率无显著差异(均p>0.05)。然而，高七氟醚亚组的躁动发生率明显高于高地氟醚亚组(33.3% vs.7.41%;P = 0.043)。结论:综上所述，对于体脂率较低的患者，地氟醚和七氟醚均可提供良好且快速的恢复;对于体脂率较高的患者，与七氟醚相比，地氟醚可以提供更好的恢复，并且躁动发生率更低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.