Thulium laser en bloc resection versus conventional transurethral resection of urinary bladder tumor: A comparative prospective study.

IF 0.7 Q4 UROLOGY & NEPHROLOGY
Urology Annals Pub Date : 2023-01-01 Epub Date: 2022-11-08 DOI:10.4103/ua.ua_59_22
Atef Badawy, Sultan Mohamed Sultan, Asem Marzouk, Eid El-Sherif
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引用次数: 2

Abstract

Background: Transurethral resection of bladder tumors (TURBT) is the standard management for urinary bladder tumors; however, new techniques as Thulium laser en bloc resection of bladder tumors (TmLRBT) have been introduced as a substitute to TURBT.

Objectives: In this study safety, efficacy, and tumor recurrence after TmLRBT and TURBT were prospectively compared in patients with primary (<4 cm) bladder tumors.

Patients and methods: Between August 2019 and May 2021, patients with primary (<4 cm) bladder tumors were enrolled. Patients were randomized between the two procedures. All perioperative data were collected prospectively. Pathological specimen findings and recurrence rates were reported during follow-up visits.

Results: Sixty patients underwent TURBT, and another 60 had TmLRBT. No significant differences were detected in patient demographics or preoperative tumor characteristics between the two groups. Operation time was less (28.2 vs. 38.9 min, P < 0.001), and rate of bladder perforation was lower with TmLRBT compared to TURBT (3.3% vs. 15.0%, P = 0.027). In the TmLRBT group, higher rate of muscle detection (95.0% vs. 78.3%, P < 0.001) in the pathological specimen, and lower rate of tissue destruction (0.0% vs. 21.6%, P < 0.001) were obtained compared to TURBT. Recurrence rate in cases of nonmuscle invasive bladder cancer was lower with TmLRBT (6.7% vs. 33.0%, P < 0.001).

Conclusion: In this study, TmLRBT showed reduced operative time with lower perforation rates. Higher detection of detrusor muscle and less tissue destruction in the pathological specimen were obtained with TmLRBT, as well as lower rates of tumor recurrence. These findings suggest that TmLRBT is a safe and efficacious substitute to TURBT in tumors <4 cm.

Abstract Image

钬激光膀胱肿瘤整体切除术与传统经尿道膀胱肿瘤切除术的比较前瞻性研究。
背景:经尿道膀胱肿瘤切除术(TURBT)是治疗膀胱肿瘤的标准方法;然而,已经引入了新的技术,如Thulium激光膀胱肿瘤整体切除术(TmLRBT)来代替TURBT。目的:在本研究中,对原发性肿瘤患者进行了TmLRBT和TURBT后肿瘤复发的前瞻性比较(患者和方法:2019年8月至2021年5月,原发性患者(结果:60名患者接受了TURBT,另有60名患者进行了TmLRBT。两组患者的人口统计学或术前肿瘤特征没有显著差异。手术时间更短TmLRBT组的膀胱穿孔率较TURBT组低(3.3%对15.0%,P=0.027)。TmLRBT治疗非肌肉浸润性癌症的复发率较低(6.7%对33.0%,P<0.001)。TmLRBT对逼尿肌的检测更高,病理标本中的组织破坏更少,肿瘤复发率更低。这些发现表明TmLRBT在肿瘤中是TURBT的安全有效的替代品
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来源期刊
Urology Annals
Urology Annals UROLOGY & NEPHROLOGY-
CiteScore
1.20
自引率
0.00%
发文量
59
审稿时长
31 weeks
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