The Use of Single Photon Emission Computed Tomography in Aerosol Medicine.

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM
John S Fleming
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引用次数: 0

Abstract

Imaging of radiolabeled aerosols provides useful in vivo data on both the initial site of deposition and its subsequent transport by mucociliary clearance and epithelial permeability. Single Photon Emission Computed Tomography (SPECT) uses a gamma camera with multiple rotating heads to produce three-dimensional (3D) images of inhaled radioaerosol labeled with technetium-99m. This enables total lung deposition and its 3D regional distribution to be quantified. Aligned 3D images of lung structure allow deposition data to be related to lung anatomy. Mucociliary clearance or epithelial permeability can be assessed from a time series of SPECT aerosol images. SPECT is slightly superior to planar imaging for measuring total lung deposition. However, it is more complex to use, and for studies where total lung deposition is the endpoint, planar imaging is recommended. However, SPECT has been shown to be clearly superior to planar imaging for assessing regional distribution of aerosol and is the method of choice for this purpose. It therefore has applications in studying the influence of regional deposition on clinical effectiveness and also in validating computer models of deposition. The inability to directly radiolabel drug molecules with 99mTc is a clear disadvantage of SPECT and limits its potential use for pharmacokinetic studies. SPECT provides a wealth of data on aerosol deposition, which has been relatively underused at present. Optimal methods of analyzing and interpreting the data need to be developed. SPECT can also, in principle, provide detailed information of mucociliary clearance and has the potential to significantly improve knowledge of this process and hence clarify the role of clearance as a biomarker.

单光子发射计算机断层扫描在气溶胶医学中的应用。
放射性标记气溶胶的成像提供了有用的体内数据,包括沉积的初始位置及其随后通过纤毛粘膜清除和上皮通透性的运输。单光子发射计算机断层扫描(SPECT)使用带有多个旋转头的伽马照相机来产生吸入放射性气溶胶的三维(3D)图像,这些气溶胶被标记为锝-99m。这样可以量化肺沉积总量及其三维区域分布。肺结构的对齐3D图像允许沉积数据与肺解剖相关。纤毛粘膜清除或上皮通透性可以从SPECT气溶胶图像的时间序列中评估。SPECT在测量全肺沉积方面略优于平面成像。然而,使用起来更复杂,对于以全肺沉积为终点的研究,建议使用平面成像。然而,SPECT已被证明在评估气溶胶的区域分布方面明显优于平面成像,并且是用于此目的的首选方法。因此,它在研究局部沉积对临床疗效的影响以及验证沉积的计算机模型方面具有应用价值。不能直接用99mTc对药物分子进行放射性标记是SPECT的一个明显缺点,限制了其在药代动力学研究中的潜在应用。SPECT提供了大量关于气溶胶沉积的数据,而这些数据目前还没有得到充分利用。需要开发分析和解释数据的最佳方法。原则上,SPECT也可以提供粘膜纤毛清除的详细信息,并有可能显著提高对这一过程的认识,从而阐明清除作为生物标志物的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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