Evaluation of the effect of antiepileptic drugs on mandibular bone quality by fractal analysis.

IF 1.6 3区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Radiology Pub Date : 2023-07-01 DOI:10.1007/s11282-023-00671-0

Berkhas Tumani Üstdal, Damla Soydan Çabuk, Aykağan Coşgunarslan, Burcu Evlice, Ahmet Evlice

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引用次数: 2

Abstract

Objectives: Antiepileptic drugs (AEDs) are used to control seizures in epilepsy and their long-term use is common. AED use has been associated with decreased bone mineral density. The aim of this study is to determine the effect of AEDs on mandibular bone quality using fractal analysis and panoramic morphometric indices.

Methods: In this study, dental and medical records of 132 patients (66 AED users and 66 control group) were used. Fractal analysis (FA), the panoramic mandibular index (PMI), mandibular cortical width (MCW), and Klemetti index (KI) measurements were performed on panoramic radiographs.

Results: In all metrics, the mean values of the study group were significantly lower than the control group (p < 0.000). There is a statistically significant difference between the study and control groups in terms of KI distribution (p < 0.000). The mean fractal dimension (FD) values in each measured region of the female patients in the study group were found to be significantly lower than the female patients in the control group (p < 0.05). The mean FD values measured in ROI-2 and ROI-3 of male patients in the study group were found to be significantly lower than male patients in the control group (p < 0.05).

Conclusion: The side effects of AEDs on bone metabolism were shown in this study. Dentists examining patients with epilepsy should be careful about osteoporotic changes in the jaws.

Abstract Image

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应用分形分析评价抗癫痫药物对下颌骨质量的影响。

目的:抗癫痫药物(AEDs)用于控制癫痫发作，长期使用较为常见。使用AED与骨密度降低有关。本研究的目的是利用分形分析和全景形态测量指数来确定AEDs对下颌骨质量的影响。方法:使用AED患者66例，对照组66例，共132例。在全景x线片上进行分形分析(FA)、下颌全景指数(PMI)、下颌皮质宽度(MCW)和Klemetti指数(KI)测量。结果:在所有指标中，研究组的平均值均显著低于对照组(p)。结论:本研究显示了AEDs对骨代谢的副作用。牙医检查癫痫患者时应注意颌骨的骨质疏松变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.20

自引率

13.60%

发文量

审稿时长

>12 weeks

期刊介绍： As the official English-language journal of the Japanese Society for Oral and Maxillofacial Radiology and the Asian Academy of Oral and Maxillofacial Radiology, Oral Radiology is intended to be a forum for international collaboration in head and neck diagnostic imaging and all related fields. Oral Radiology features cutting-edge research papers, review articles, case reports, and technical notes from both the clinical and experimental fields. As membership in the Society is not a prerequisite, contributions are welcome from researchers and clinicians worldwide.

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