Jôice Dias Corrêa, Giovanna Araújo Faria, Leticia Ladeia Fernandes
{"title":"The oral microbiota and gestational diabetes mellitus.","authors":"Jôice Dias Corrêa, Giovanna Araújo Faria, Leticia Ladeia Fernandes","doi":"10.3389/fcdhc.2023.1120920","DOIUrl":null,"url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) is one of the most frequent endocrine conditions during pregnancy. GDM is linked to adverse pregnancy outcomes and has implications for maternal health. Studies have demonstrated the link between pathogenic periodontal bacteria, glycemic control, and the risk of diabetes. The objective of the current study is to perform a mini-review of the available literature on the potential changes in the oral microbiota of women with GDM. The review was conducted by two independent reviewers (LLF and JDC). Indexed electronic databases (PubMed/Medline, Cochrane Library, Web of Science, and Scopus) were searched, including articles published in English and Portuguese. A manual search was also performed to identify related articles. The oral microbial community of pregnant women with GDM is unique from that of healthy pregnant women. The majority of the alterations found in the oral microbiota of women with GDM point to a pro-inflammatory environment with high levels of bacteria associated with periodontitis (<i>Prevotella, Treponema</i>, anaerobic bacteria) and a depletion of bacteria associated with periodontal health maintenance (Firmicutes, <i>Streptococcus, Leptotrichia).</i> More well-designed studies differentiating between pregnant women with good oral health and those with periodontitis are needed to ascertain which differences are due to GDM or periodontitis.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"4 ","pages":"1120920"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012133/pdf/","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in clinical diabetes and healthcare","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fcdhc.2023.1120920","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Gestational diabetes mellitus (GDM) is one of the most frequent endocrine conditions during pregnancy. GDM is linked to adverse pregnancy outcomes and has implications for maternal health. Studies have demonstrated the link between pathogenic periodontal bacteria, glycemic control, and the risk of diabetes. The objective of the current study is to perform a mini-review of the available literature on the potential changes in the oral microbiota of women with GDM. The review was conducted by two independent reviewers (LLF and JDC). Indexed electronic databases (PubMed/Medline, Cochrane Library, Web of Science, and Scopus) were searched, including articles published in English and Portuguese. A manual search was also performed to identify related articles. The oral microbial community of pregnant women with GDM is unique from that of healthy pregnant women. The majority of the alterations found in the oral microbiota of women with GDM point to a pro-inflammatory environment with high levels of bacteria associated with periodontitis (Prevotella, Treponema, anaerobic bacteria) and a depletion of bacteria associated with periodontal health maintenance (Firmicutes, Streptococcus, Leptotrichia). More well-designed studies differentiating between pregnant women with good oral health and those with periodontitis are needed to ascertain which differences are due to GDM or periodontitis.
妊娠期糖尿病(GDM)是妊娠期最常见的内分泌疾病之一。妊娠糖尿病与不良妊娠结局有关,对孕产妇健康有影响。研究已经证明了牙周致病菌、血糖控制和糖尿病风险之间的联系。当前研究的目的是对GDM女性口腔微生物群潜在变化的现有文献进行一次小型回顾。该审查由两个独立的审查者(LLF和JDC)进行。检索了索引电子数据库(PubMed/Medline、Cochrane Library、Web of Science和Scopus),包括以英语和葡萄牙语发表的文章。还进行了人工搜索以确定相关文章。妊娠糖尿病孕妇的口腔微生物群落与健康孕妇不同。在患有GDM的女性口腔微生物群中发现的大多数改变表明,在促炎环境中,与牙周炎相关的细菌(普雷沃氏菌、密螺旋体、厌氧细菌)水平较高,与牙周健康维持相关的细菌(厚壁菌门、链球菌、钩毛菌)数量减少。需要更多精心设计的研究来区分口腔健康良好的孕妇和患有牙周炎的孕妇,以确定哪些差异是由GDM或牙周炎引起的。