Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Redox Report Pub Date : 2022-12-01 DOI:10.1080/13510002.2022.2123882

Sebastian Bańkowski, Miroslav Petr, Michał Rozpara, Ewa Sadowska-Krępa

{"title":"Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners.","authors":"Sebastian Bańkowski, Miroslav Petr, Michał Rozpara, Ewa Sadowska-Krępa","doi":"10.1080/13510002.2022.2123882","DOIUrl":null,"url":null,"abstract":"Background: The study was undertaken to evaluate the effect of 6-week supplementation with a daily dose of 2g of curcumin on VO2max and prooxidant/antioxidant homeostasis in middle-aged amateur long-distance runners during the preparatory period of the macrocycle.Methods: Thirty runners were randomly assigned to a placebo group (PL) and a curcumin-supplemented group (CU). Their VO2max was assessed before supplementation and after 6 weeks of supplementation. Venous blood samples were collected from the participants at rest, immediately after exercise, and after 1h of recovery to evaluate the activity of antioxidant enzymes (SOD, CAT, GPx), non-enzymatic antioxidants (GSH, UA) and sirtuin 3 level (SIRT 3), as well as the levels of oxidative stress markers (TOS/TOC, MDA, and 8-OHdG) and muscle damage markers (CK, LDH, and Mb).Results: VO2max, the activity of enzymatic antioxidants, the concentrations of non-enzymatic antioxidants, the levels of oxidative stress markers, and the levels of muscle damage markers did not change significantly in the CU group over 6 weeks of supplementation with curcumin. However, the resting concentration of SIRT 3 was found to be significantly higher (p ≤ 0.05) compared with pre-supplementation.Conclusion: Curcumin supplementation does not have a significant effect on VO2max and prooxidant/antioxidant homeostasis in runners.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"27 1","pages":"186-192"},"PeriodicalIF":5.2000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518241/pdf/","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Redox Report","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/13510002.2022.2123882","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 3

Abstract

Background: The study was undertaken to evaluate the effect of 6-week supplementation with a daily dose of 2g of curcumin on VO_2max and prooxidant/antioxidant homeostasis in middle-aged amateur long-distance runners during the preparatory period of the macrocycle.

Methods: Thirty runners were randomly assigned to a placebo group (PL) and a curcumin-supplemented group (CU). Their VO_2max was assessed before supplementation and after 6 weeks of supplementation. Venous blood samples were collected from the participants at rest, immediately after exercise, and after 1h of recovery to evaluate the activity of antioxidant enzymes (SOD, CAT, GPx), non-enzymatic antioxidants (GSH, UA) and sirtuin 3 level (SIRT 3), as well as the levels of oxidative stress markers (TOS/TOC, MDA, and 8-OHdG) and muscle damage markers (CK, LDH, and Mb).

Results: VO_2max, the activity of enzymatic antioxidants, the concentrations of non-enzymatic antioxidants, the levels of oxidative stress markers, and the levels of muscle damage markers did not change significantly in the CU group over 6 weeks of supplementation with curcumin. However, the resting concentration of SIRT 3 was found to be significantly higher (p ≤ 0.05) compared with pre-supplementation.

Conclusion: Curcumin supplementation does not have a significant effect on VO_2max and prooxidant/antioxidant homeostasis in runners.

查看原文本刊更多论文

6周补充姜黄素对中年业余长跑运动员有氧能力、抗氧化状态和sirtuin 3水平的影响。

背景:本研究旨在评估在大周期准备阶段，中年业余长跑运动员在6周内每天补充2g姜黄素对VO2max和促氧化/抗氧化稳态的影响。方法:30名跑步者随机分为安慰剂组(PL)和姜黄素补充组(CU)。在补充前和补充6周后评估他们的VO2max。分别在休息、运动后和恢复后1小时采集静脉血，评估抗氧化酶(SOD、CAT、GPx)、非酶抗氧化剂(GSH、UA)和sirtuin 3水平的活性，以及氧化应激标志物(TOS/TOC、MDA和8-OHdG)和肌肉损伤标志物(CK、LDH和Mb)的水平。结果:在补充姜黄素6周后，CU组的VO2max、酶促抗氧化剂活性、非酶促抗氧化剂浓度、氧化应激标志物水平和肌肉损伤标志物水平均无显著变化。然而，与补充前相比，SIRT - 3的静息浓度显著升高(p≤0.05)。结论:补充姜黄素对跑步者的VO2max和促氧化/抗氧化稳态没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.