Pregnancy Course of 10 Women Diagnosed with Chronic Lymphocytic Leukemia.

IF 1.7 4区 医学 Q3 HEMATOLOGY
Acta Haematologica Pub Date : 2023-01-01 Epub Date: 2023-06-05 DOI:10.1159/000531400
Tamar Tadmor, Guy Melamed, Hillel Alapi, Sivan Gazit, Tal Patalon, Lior Rokach
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引用次数: 0

Abstract

Pregnancies following diagnosis of chronic lymphocytic leukemia (CLL) are rare events, mainly because the disease is typically diagnosed in the elderly. Literature on the topic is based only on case reports, and limited data are available on the influence of pregnancy on CLL course. In this retrospective study, we aimed to summarize the clinical and laboratory course of 10 women with CLL who became pregnant. None of the patients had significant changes in blood count during or after pregnancy or had complications such as infection, autoimmune phenomenon, or preeclampsia. Four out of 10 pregnancies were terminated with an early miscarriage. Following labor, 1 patient started anti-CLL treatment due to preexisting anemia, but none of the women required therapy during CLL progression during the first 2 years of follow-up. We conclude that based on our serial, pregnancy does not negatively impact on CLL course.

Abstract Image

10例被诊断为慢性淋巴细胞白血病妇女的妊娠过程。
诊断为慢性淋巴细胞白血病(CLL)后的妊娠是罕见的事件,主要是因为这种疾病通常在老年人中诊断。有关该主题的文献仅基于病例报告,关于妊娠对CLL进程的影响的数据有限。在这项回顾性研究中,我们旨在总结10名CLL孕妇的临床和实验室过程。没有一名患者在怀孕期间或怀孕后的血细胞计数发生显著变化,也没有出现感染、自身免疫现象或先兆子痫等并发症。10例妊娠中有4例因早期流产而终止妊娠。分娩后,1名患者因先前存在的贫血而开始抗CLL治疗,但在前2年的随访中,没有一名女性在CLL进展过程中需要治疗。我们的结论是,根据我们的系列,怀孕不会对CLL进程产生负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Haematologica
Acta Haematologica 医学-血液学
CiteScore
4.90
自引率
0.00%
发文量
61
审稿时长
6-12 weeks
期刊介绍: ''Acta Haematologica'' is a well-established and internationally recognized clinically-oriented journal featuring balanced, wide-ranging coverage of current hematology research. A wealth of information on such problems as anemia, leukemia, lymphoma, multiple myeloma, hereditary disorders, blood coagulation, growth factors, hematopoiesis and differentiation is contained in first-rate basic and clinical papers some of which are accompanied by editorial comments by eminent experts. These are supplemented by short state-of-the-art communications, reviews and correspondence as well as occasional special issues devoted to ‘hot topics’ in hematology. These will keep the practicing hematologist well informed of the new developments in the field.
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