Associations Between Systemic Inflammatory Markers Based on Blood Cells and Polysomnographic Factors in Obstructive Sleep Apnea.

IF 2.9 3区医学 Q1 OTORHINOLARYNGOLOGY

Clinical and Experimental Otorhinolaryngology Pub Date : 2023-05-01 DOI:10.21053/ceo.2022.01368

Minju Kim, Sung-Woo Cho, Tae-Bin Won, Chae-Seo Rhee, Jeong-Whun Kim

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引用次数: 1

Abstract

Objectives: Systemic inflammation plays a key role in the pathogenesis of obstructive sleep apnea (OSA); however, easy-to-use methods to evaluate the severity of systemic inflammation have yet to be developed. This study investigated the association between systemic inflammation markers that could be derived from the complete blood count (CBC) profile and sleep parameters in a large number of patients with OSA.

Methods: Patients who visited our hospital's Otorhinolaryngology Sleep Clinic between January 2017 and April 2022 underwent polysomnography and routine laboratory tests, including a CBC. Associations between three systemic inflammatory markers-the systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR)-and polysomnographic and demographic factors including age, sex, body mass index, the apnea-hypopnea index (AHI), the hypopnea index (HI), lowest oxygen saturation (%), the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale, and percentages of non-rapid eye movement (REM) sleep stage 3, REM sleep, and snoring time were analyzed. The inflammation markers were compared among OSA subgroups, and associations were also analyzed in subgroups with different OSA severities.

Results: In total, 1,102 patients (968 men and 134 women) were included, and their mean AHI was 33.0±24.3. PSQI was significantly associated with SII (P=0.027). No independent significant factors were identified for the NLR or PLR. Within the simple snoring and mild OSA subgroups, no significant association was found between sleep parameters and the SII. In the severe OSA subgroup, the AHI (P=0.004) and PSQI (P=0.012) were independently associated with the SII.

Conclusion: Our study analyzed systemic inflammatory markers based on the CBC, a simple, relatively cost-effective test, and showed that the AHI and SII were significantly correlated only in the severe OSA subgroup.

查看原文本刊更多论文

阻塞性睡眠呼吸暂停中基于血细胞和多导睡眠图因子的全身炎症标志物之间的关系。

目的:全身性炎症在阻塞性睡眠呼吸暂停(OSA)的发病机制中起关键作用;然而，评估全身性炎症严重程度的简便方法尚未开发。本研究调查了大量OSA患者全血细胞计数(CBC)与睡眠参数之间的关系。方法:2017年1月至2022年4月至我院耳鼻喉科睡眠门诊就诊的患者进行了多导睡眠图和常规实验室检查，包括CBC。三种全身炎症标志物——全身免疫炎症指数(SII)、中性粒细胞-淋巴细胞比率(NLR)和血小板-淋巴细胞比率(PLR)——与多导睡眠图和人口统计学因素(包括年龄、性别、体重指数、呼吸暂停-低呼吸指数(AHI)、低呼吸指数(HI)、最低血氧饱和度(%)、匹兹堡睡眠质量指数(PSQI)、爱普沃斯嗜睡量表、非快速眼动(REM)睡眠阶段3、REM睡眠阶段、并对打鼾时间进行分析。比较不同OSA亚组间的炎症指标，并分析不同OSA严重程度亚组间的相关性。结果:共纳入1102例患者(男性968例，女性134例)，平均AHI为33.0±24.3。PSQI与SII显著相关(P=0.027)。未发现影响NLR或PLR的独立显著因素。在单纯打鼾和轻度OSA亚组中，睡眠参数与SII之间未发现显著关联。在严重OSA亚组中，AHI (P=0.004)和PSQI (P=0.012)与SII独立相关。结论:我们的研究分析了基于CBC的全身性炎症标志物，这是一种简单、成本相对较低的测试，结果显示AHI和SII仅在严重OSA亚组中存在显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Otorhinolaryngology 医学-耳鼻喉科学

CiteScore

4.90

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Otorhinolaryngology (Clin Exp Otorhinolaryngol, CEO) is an international peer-reviewed journal on recent developments in diagnosis and treatment of otorhinolaryngology-head and neck surgery and dedicated to the advancement of patient care in ear, nose, throat, head, and neck disorders. This journal publishes original articles relating to both clinical and basic researches, reviews, and clinical trials, encompassing the whole topics of otorhinolaryngology-head and neck surgery. CEO was first issued in 2008 and this journal is published in English four times (the last day of February, May, August, and November) per year by the Korean Society of Otorhinolaryngology-Head and Neck Surgery. The Journal aims at publishing evidence-based, scientifically written articles from different disciplines of otorhinolaryngology field. The readership contains clinical/basic research into current practice in otorhinolaryngology, audiology, speech pathology, head and neck oncology, plastic and reconstructive surgery. The readers are otolaryngologists, head and neck surgeons and oncologists, audiologists, and speech pathologists.