The potential regulatory role of RNA methylation in ovarian cancer.

IF 3.6 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

RNA Biology Pub Date : 2023-01-01 DOI:10.1080/15476286.2023.2213915

Shijie Zhao, Mengxue Zhang, Xiaolan Zhu, Jie Xing, Jiaming Zhou, Xinming Yin

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引用次数: 1

Abstract

Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification. RNA methylation is essential for regulating biological processes such as RNA transcription, splicing, structure, stability, and translation. Its dysfunction is strongly associated with the development of human malignancies. Research advances with respect to the regulatory role of RNA modifications in ovarian cancer include N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), and N7-methylguanosine (m7G). Numerous studies have demonstrated that epigenetic modifications of RNA can influence the progression and metastasis of ovarian cancer and may provide excellent targets for cancer therapy. This review highlights advances in research on RNA methylation modifications and ovarian cancer prognosis, carcinogenesis, and resistance, which could provide a theoretical foundation for designing therapeutic strategies for ovarian cancer based on RNA methylation modifications.

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RNA甲基化在卵巢癌中的潜在调节作用。

全基因组测序技术的更新揭示了癌症中多种RNA修饰，其中RNA甲基化是一种常见的转录后修饰。RNA甲基化对于调节RNA转录、剪接、结构、稳定性和翻译等生物过程至关重要。它的功能障碍与人类恶性肿瘤的发展密切相关。关于RNA修饰在卵巢癌中的调控作用的研究进展包括n6 -甲基腺苷(m6A)、5-甲基胞嘧啶(m5C)、n1 -甲基腺苷(m1A)和n7 -甲基鸟苷(m7G)。大量研究表明，RNA的表观遗传修饰可以影响卵巢癌的进展和转移，并可能为癌症治疗提供良好的靶点。本文综述了RNA甲基化修饰与卵巢癌预后、癌变及耐药的研究进展，为设计基于RNA甲基化修饰的卵巢癌治疗策略提供理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

RNA Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy

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