Santiago Giménez-Roldán, Valerie S Palmer, Peter S Spencer
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引用次数: 0
Abstract
After the end of the Spanish Civil War (1936-1939), an estimated 1,000 patients presented with lathyrism due to their excessive and prolonged consumption of grasspea (Lathyrus sativus L.) against the backdrop of poverty, drought, and famine. Based on 68 scientific communications between 1941 and 1962 by qualified medical professionals, the disease emerged in different geographical locations involving selective populations: (1) farmers from extensive areas of central Spain, traditionally producers and consumers of grasspea; (2) immigrants in the industrial belt of Catalonia and in the Basque Country, areas with little or no production of grasspea, which was imported from producing areas; (3) workers in Galicia, an area where the legume is neither produced nor consumed, who were seasonally displaced to high-production areas of grasspea in Castille; and (4) inmates of overcrowded postwar Spanish prisons. Original reports included failed attempts by Carlos Jiménez Díaz (1898-1967) to induce experimental lathyrism, the neuropathology of lathyrism in early stages of the disease in two patients, as reported by Carlos Oliveras de la Riva (1914-2007), and the special susceptibility of children to develop a severe form of lathyrism after relatively brief periods of consumption of the neurotoxic seed of L. sativus. In the Spanish Basque Country, L. cicera L. (aizkol) was cultivated exclusively as animal fodder. Patients who were forced to feed on this plant developed unusual manifestations of lathyrism, such as axial myoclonus and severe neuropsychiatric disorders, unknown in other regions of the country and previously unreported. The postwar epidemic of lathyrism in Spain represents the most extensively studied outbreak of this self-limiting but crippling upper motor neuron disease.
期刊介绍:
The Journal of the History of the Neurosciences is the leading communication platform dealing with the historical roots of the basic and applied neurosciences. Its domains cover historical perspectives and developments, including biographical studies, disorders, institutions, documents, and instrumentation in neurology, neurosurgery, neuropsychiatry, neuroanatomy, neurophysiology, neurochemistry, neuropsychology, and the behavioral neurosciences. The history of ideas, changes in society and medicine, and the connections with other disciplines (e.g., the arts, philosophy, psychology) are welcome. In addition to original, full-length papers, the journal welcomes informative short communications, letters to the editors, book reviews, and contributions to its NeuroWords and Neurognostics columns. All manuscripts are subject to initial appraisal by an Editor, and, if found suitable for further consideration, full- and short-length papers are subject to peer review (double blind, if requested) by at least 2 anonymous referees.