An Alternative Approach to Tablet Splitting and Grinding for Medication Administration.

Q4 Medicine
Rajneesh Taneja, Joseph Scarim, Poonam G Pande, Anthony Scarim, Milap C Nahata, Rita K Jew, Koteswara Rao Inabathina
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引用次数: 0

Abstract

Tablet formulations fail to meet the needs of patients unable to swallow tablets such as pediatric, elderly, and patients that must receive medications via feeding tubes. Our objective was to develop and test a new, simple device (XTEMP-R) and the methodology for converting tablets into a homogeneous suspension for medication administration. We developed a new device comprised of a flexible receptacle, a tight-fitting cap, and a suction cup bottom to convert tablets into liquid preparations. Tuberculosis treatment drugs, TBAJ-876 and TBI-223, were dispersed within the device utilizing water and commonly available suspending vehicles. We investigated the effectiveness of the XTEMP-R device in dispersing tablets. This was accomplished by visual observations, determining the fineness of dispersion, and measuring the total drug recovery from the dispersions in XTEMP-R. We investigated the accuracy and reproducibility of delivering aliquots from these suspensions by determining the dose reproducibility upon suspension and upon redispersion after 24 hours. The effectiveness of the device was also evaluated using commercially available tablets of acetaminophen, amlodipine, glimepiride, metformin, and valsartan. The suspensions were visually uniform without any large particles. The suspensions passed through a #18 sieve confirming that the particles were less than 1000 µm. The average total dose recovery of three suspensions each was determined to be 101.3% and 99.2% for TBI-223 and TBAJ-876, respectively. Reproducibility from aliquots of 2 mL each was 98.9% to 99.7% for three replicates of TBI-223 suspensions, and 102.6% to 103.2% for TBAJ-876 suspensions. Aliquots tested after 24 hours confirmed uniform redispersibility. We have demonstrated that XTEMP-R can be utilized to prepare homogeneous suspensions conveniently and efficiently in less than 10 minutes without any drug loss. Aliquots for partial dose delivery can be withdrawn accurately. These findings demonstrate that XTEMP-R can be used to accurately deliver doses of suspensions for patients who cannot swallow tablets.

一种用于给药的片剂拆分研磨的替代方法。
片剂配方不能满足不能吞咽片剂的患者的需求,如儿童、老年人和必须通过喂食管接受药物治疗的患者。我们的目标是开发和测试一种新的、简单的设备(XTEMP-R)和方法,将片剂转化为均匀的悬浮液用于给药。我们开发了一种新的装置,由一个灵活的容器、一个紧密的盖子和一个吸盘底部组成,可以将药片转化为液体制剂。结核治疗药物TBAJ-876和TBI-223利用水和常用的悬浮车辆分散在装置内。我们考察了XTEMP-R装置在分散片中的有效性。这是通过目视观察,确定分散体的细度,并测量XTEMP-R中分散体的总药物回收率来完成的。通过测定悬浮液和24小时后再分散时的剂量再现性,我们研究了从这些悬浮液中递送等量的准确性和再现性。还使用市售的对乙酰氨基酚、氨氯地平、格列美脲、二甲双胍和缬沙坦片评估了该装置的有效性。悬浮液在视觉上均匀,没有任何大颗粒。悬浮液通过18号筛,确认颗粒小于1000µm。TBI-223和TBAJ-876三种混悬液的平均总剂量回收率分别为101.3%和99.2%。TBI-223混悬液的重复性为98.9% ~ 99.7%,TBAJ-876混悬液的重复性为102.6% ~ 103.2%。24小时后测试的等价物确认了均匀的再分散性。我们已经证明,XTEMP-R可以在不到10分钟的时间内方便有效地制备均匀的混悬液,而不会有任何药物损失。可准确地提取部分剂量分配的等价物。这些发现表明,XTEMP-R可以用于准确地为不能吞咽片剂的患者提供混悬剂剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
62
期刊介绍: The International Journal of Pharmaceutical Compounding (IJPC) is a bi-monthly, scientific and professional journal emphasizing quality pharmaceutical compounding. IJPC is the only publication that covers pharmaceutical compounding topics relevant and necessary to empower pharmacists to meet the needs of today"s patients. No other publication features hands-on, how-to compounding techniques or the information that contemporary pharmacists need to provide individualized care.
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