False negative effect of high triglycerides concentration on vitamin D levels: A big data study.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-03-15 DOI:10.5937/jomb0-40106

Murat Çağlayan, Ataman Gonel, Tugba Songul Tat, Osman Celik, Fidanci Ali Aykut, Ayvali Mustafa Okan, Ulgu Mustafa Mahir, Naim Ata, Suayip Birinci

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引用次数: 1

Abstract

Background: Inaccurate test results may be a reason why vitamin D deficiency is seen as a common problem worldwide. Interferences from the sample matrix during testing are the most important factors in measurement errors. In this study, the relationship between triglycerides and total cholesterol levels and vitamin D levels in Turkey was investigated.

Methods: The 25-hydroxyvitamin D test results and lipid test results studied in Turkey in 2021 were compared. Data were obtained from the Ministry of Health National Health Database. Simultaneously, 25-hydroxyvitamin D, triglyceride, and total cholesterol levels were studied, and 1,135,644 test results were taken as the basis.

Results: In the group of patients with total cholesterol levels between 0-10.33 mmol/L, the proportion of patients below 20 mg/L ranged from 56.8% to 61.8%. In the patient group with cholesterol between 10.36-259 mmol/L, the rate of patients with less than 20 mg/L was between 70.8-100%, while the rate of patients with cholesterol above 100 mg/L was 0%. The mean 25-hydroxyvitamin D level was 20.1 mg/L in the patient group with a total cholesterol level between 0-10.33 mmol/L, and 16 mg/L in the patient group with a cholesterol level above 10.36 mmol/L. The mean 25-hydroxyvitamin D level was 20.11 mg/L in the patient group with triglycerides 0-10.16 mmol/L, and the 25-hydroxyvitamin D level was 12.28 mg/L in the patient group with triglycerides 10.17-113 mmol/L. The proportion of patients with vitamin D levels above 100 mg/L was found to be 0% in the group of patients with triglycerides above 10.17-113 mmol/L.

Conclusions: According to this study, there is a risk of toxicity when administering vitamin D therapy in patients with high cholesterol and triglycerides levels. This study is the first of this size in the literature. High triglycerides and cholesterol levels can cause inaccurate measurement of vitamin D levels, so care should be taken when evaluating these tests.

查看原文本刊更多论文

高甘油三酯浓度对维生素D水平的假阴性影响:一项大数据研究。

背景:不准确的测试结果可能是维生素D缺乏被视为全球普遍问题的原因。在测试过程中，来自样品矩阵的干扰是造成测量误差的最重要因素。在这项研究中，甘油三酯和总胆固醇水平和维生素D水平之间的关系在土耳其进行了调查。方法:比较2021年土耳其25-羟基维生素D检测结果和脂质检测结果。数据来自卫生部国家卫生数据库。同时，研究了25-羟基维生素D、甘油三酯和总胆固醇水平，并以1,135,644个检测结果为依据。结果:在总胆固醇水平0 ~ 10.33 mmol/L的患者组中，低于20 mg/L的患者比例为56.8% ~ 61.8%。在胆固醇为10.36-259 mmol/L的患者组中，低于20 mg/L的患者比例为70.8-100%，高于100 mg/L的患者比例为0%。总胆固醇水平在0 ~ 10.33 mmol/L的患者组25-羟基维生素D平均水平为20.1 mg/L，高于10.36 mmol/L的患者组25-羟基维生素D平均水平为16 mg/L。甘油三酯0 ~ 10.16 mmol/L患者组25-羟基维生素D平均水平为20.11 mg/L，甘油三酯10.17 ~ 113 mmol/L患者组25-羟基维生素D平均水平为12.28 mg/L。在甘油三酯高于10.17-113 mmol/L的患者组中，维生素D水平高于100 mg/L的患者比例为0%。结论:根据这项研究，对高胆固醇和甘油三酯水平的患者进行维生素D治疗有毒性风险。这是文献中第一个如此规模的研究。高甘油三酯和胆固醇水平会导致维生素D水平测量不准确，所以在评估这些测试时应该小心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.