Role of natural killer and B cell interaction in inducing pathogen specific immune responses.

IF 4.3 4区 医学 Q2 IMMUNOLOGY
Nikunj Tandel, Sushmita Negi, Sarat K Dalai, Rajeev K Tyagi
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引用次数: 2

Abstract

The innate lymphoid cell (ILC) system comprising of the circulating and tissue-resident cells is known to clear infectious pathogens, establish immune homeostasis as well as confer antitumor immunity. Human natural killer cells (hNKs) and other ILCs carry out mopping of the infectious pathogens and perform cytolytic activity regulated by the non-adaptive immune system. The NK cells generate immunological memory and rapid recall response tightly regulated by the adaptive immunity. The interaction of NK and B cell, and its role to induce the pathogen specific immunity is not fully understood. Hence, present article sheds light on the interaction between NK and B cells and resulting immune responses in the infectious diseases. The immune responses elicited by the NK-B cell interaction is of particular importance for developing therapeutic vaccines against the infectious pathogens. Further, experimental evidences suggest the immune-response driven by NK cell population elicits the host-specific antibodies and memory B cells. Also, recently developed humanized immune system (HIS) mice and their importance in to understanding the NK-B cell interaction and resulting pathogen specific immunity has been discussed.

自然杀手和B细胞相互作用在诱导病原体特异性免疫反应中的作用。
先天淋巴样细胞(ILC)系统由循环细胞和组织驻留细胞组成,可以清除感染性病原体,建立免疫稳态,并赋予抗肿瘤免疫。人类自然杀伤细胞(hNKs)和其他ilc在非适应性免疫系统的调节下对感染性病原体进行清除和细胞溶解活动。NK细胞产生的免疫记忆和快速回忆反应受到适应性免疫的严格调控。NK细胞与B细胞的相互作用及其诱导病原体特异性免疫的作用尚不完全清楚。因此,本文揭示了NK细胞和B细胞之间的相互作用以及在感染性疾病中产生的免疫反应。NK-B细胞相互作用所引起的免疫应答对于开发针对感染性病原体的治疗性疫苗具有特别重要的意义。此外,实验证据表明NK细胞群驱动的免疫反应引发宿主特异性抗体和记忆B细胞。此外,最近发展的人源化免疫系统(HIS)小鼠及其在理解NK-B细胞相互作用和由此产生的病原体特异性免疫中的重要性也进行了讨论。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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