Impact of viral co-infection on clinical outcomes and mortality of COVID-19 patients: a study from Saudi Arabia.

IF 2 Q3 RESPIRATORY SYSTEM

Multidisciplinary Respiratory Medicine Pub Date : 2023-01-17 DOI:10.4081/mrm.2023.915

Usama E Abu Elhassan, Saad M A Alqahtani, Naif S Al Saglan, Ali Hawan, Khadejah M Alshahrani, Hana S Al-Malih, Mohammed A Alshehri, Faisal S Alqahtani, Fatimah Alshomrani, Roaa S Almtheeb, Ibrahim H E Feteih, Magda S R Abdelwahab, Ibrahim M A Mahmoud

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引用次数: 0

Abstract

Background: In COVID-19 patients undetected co-infections may have severe clinical implications associated with prolonged hospitalization, ICU admission, and mortality. Therefore, we aimed to investigate the impact of viral coinfections on the outcomes of hospitalized patients with COVID-19 in a large tertiary Saudi Arabian Hospital.

Methods: A total of 178 adult patients with confirmed SARS-CoV-2 who were hospitalized at the Armed Forces Hospital Southern Region (AFHSR), Saudi Arabia, from March 1^st to June 30^th 2022, were enrolled. Real-time PCR for the detection of viral co‑infections was carried out. Cases (SARS-CoV-2 with viral coinfections) and control (SARS-CoV-2 mono-infection) groups were compared.

Results: 12/178 (7%) of enrolled COVID-19 patients had viral coinfections. 82/178 (46%) of patients were males. 58% of patients had comorbidities. During the study period, 4/12 (33%) and 21/166 (13%) cases and control patients died, p=0.047, respectively. Duration of hospitalization was the only significant independent factor associated with SARS-CoV-2 coinfections, OR 1.140, 95% CI 1.020-1.274, p=0.021.

Conclusions: The findings of this study from a large tertiary Saudi Arabian Center revealed a prevalence of 7% for SARS-CoV-2 viral coinfections. SARS-CoV-2 coinfected patients had a significantly prolonged duration of hospitalization and higher mortality than those with SARS-CoV-2 alone. Future studies are needed.

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病毒合并感染对COVID-19患者临床结局和死亡率的影响:来自沙特阿拉伯的一项研究

背景:在COVID-19患者中，未被发现的合并感染可能具有严重的临床意义，与长期住院、ICU住院和死亡率相关。因此，我们的目的是研究病毒合并感染对沙特阿拉伯一家大型三级医院COVID-19住院患者预后的影响。方法:选取2022年3月1日至6月30日在沙特阿拉伯南部武装部队医院(AFHSR)住院的成年确诊SARS-CoV-2患者178例。采用实时荧光定量PCR检测病毒共感染。将病例(合并病毒感染的SARS-CoV-2)与对照组(单一感染的SARS-CoV-2)进行比较。结果:纳入的COVID-19患者中有12/178(7%)存在病毒合并感染。男性82/178(46%)。58%的患者有合并症。研究期间，4/12(33%)例死亡，21/166(13%)例死亡，p=0.047。住院时间是与SARS-CoV-2合并感染相关的唯一显著独立因素，OR为1.140,95% CI为1.020-1.274,p=0.021。结论:这项来自沙特阿拉伯一家大型三级中心的研究结果显示，SARS-CoV-2病毒合并感染的患病率为7%。与单独感染SARS-CoV-2的患者相比，合并感染SARS-CoV-2的患者住院时间明显延长，死亡率更高。需要进一步的研究。

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来源期刊

Multidisciplinary Respiratory Medicine 医学-呼吸系统

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.