A Longitudinal Assessment of the Natural Change in Haemoglobin, Haematocrit, and Mean Corpuscular Volume with Age.

IF 1.7 4区医学 Q3 HEMATOLOGY

Acta Haematologica Pub Date : 2023-01-01 DOI:10.1159/000529356

Idan Goldberg, Eytan Cohen, Anat Gafter-Gvili, Tzippy Shochat, Eitan Kugler, Ili Margalit, Elad Goldberg, Pia Raanani, Ilan Krause

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引用次数: 1

Abstract

Introduction: We aimed to assess the natural annual trends in the levels of haemoglobin, haematocrit, and mean corpuscular volume (MCV) in a population of adults, together with the influence of different clinical parameters on these trends.

Methods: A retrospective analysis was carried out on data from a large cohort of subjects attending a screening centre in Israel. For each subject, the yearly average change of haemoglobin, haematocrit, and MCV was calculated. Statistical analysis was performed for the whole cohort and for different subgroups.

Results: The study included 3,551 subjects. The average annual rates of decline were found to be -0.0550 g/dL (95% confidence interval [CI] -0.0590 g/dL to -0.0503 g/dL) and -0.097% (95% CI -0.112% to -0.083%) for haemoglobin and haematocrit, respectively. An average annual increase in the MCV level by 0.184 fL (95% CI 0.168 fL-0.200 fL) was found. Among men, the rate of decline in haemoglobin was found to be twice as high compared with women -0.06 g/dL versus -0.03 g/dL, respectively (p = 0.0063). In a multivariate analysis, gender remained the only parameter significantly associated with the annual decline of haemoglobin (p = 0.0001).

Conclusion: An annual average decrease in the levels of haemoglobin and haematocrit together with an annual increase in MCV was found. These changes were more prominent in men.

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血红蛋白、红细胞压积和平均红细胞体积随年龄自然变化的纵向评估。

前言:我们旨在评估成人人群中血红蛋白、红细胞压积和平均红细胞体积(MCV)水平的自然年趋势，以及不同临床参数对这些趋势的影响。方法:回顾性分析来自以色列筛查中心的大队列受试者的数据。计算每个受试者血红蛋白、红细胞压积和MCV的年平均变化。对整个队列和不同亚组进行统计分析。结果:共纳入3551名受试者。血红蛋白和红细胞压积的年平均下降率分别为-0.0550 g/dL(95%可信区间[CI] -0.0590 g/dL至-0.0503 g/dL)和-0.097% (95% CI -0.112%至-0.083%)。发现MCV水平平均每年增加0.184 fL (95% CI 0.168 fL-0.200 fL)。在男性中，血红蛋白的下降率是女性的两倍，分别为-0.06 g/dL和-0.03 g/dL (p = 0.0063)。在多变量分析中，性别仍然是唯一与血红蛋白年下降显著相关的参数(p = 0.0001)。结论:发现血红蛋白和红细胞压积水平的年平均下降与MCV的年平均上升。这些变化在男性中更为明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Haematologica 医学-血液学

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Acta Haematologica'' is a well-established and internationally recognized clinically-oriented journal featuring balanced, wide-ranging coverage of current hematology research. A wealth of information on such problems as anemia, leukemia, lymphoma, multiple myeloma, hereditary disorders, blood coagulation, growth factors, hematopoiesis and differentiation is contained in first-rate basic and clinical papers some of which are accompanied by editorial comments by eminent experts. These are supplemented by short state-of-the-art communications, reviews and correspondence as well as occasional special issues devoted to ‘hot topics’ in hematology. These will keep the practicing hematologist well informed of the new developments in the field.