Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline.

IF 3.9 4区医学 Q2 NEUROSCIENCES

ASN NEURO Pub Date : 2023-01-01 DOI:10.1177/17590914231155976

G C Nascimento, M Bortolanza, A Bribian, G C Leal-Luiz, R Raisman-Vozari, L López-Mascaraque, E Del-Bel

引用次数: 1

Abstract

Summary statement: NG2-glia alters its dynamics in response to L-DOPA-induced dyskinesia. In these animals, striatal NG2-glia density was reduced with cells presenting activated phenotype while doxycycline antidyskinetic therapy promotes a return to NG2-glia cell density and protein to a not activated state.

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左旋多巴诱导帕金森大鼠运动障碍时纹状体ng2神经胶质的动态参与:强力霉素的影响。

摘要:ng2 -胶质细胞在左旋多巴诱导的运动障碍中改变其动力学。在这些动物中，纹状体ng2 -胶质细胞密度降低，细胞呈现激活表型，而强力霉素抗运动障碍治疗可促进ng2 -胶质细胞密度和蛋白质恢复到非激活状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ASN NEURO NEUROSCIENCES-

CiteScore

7.70

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： ASN NEURO is an open access, peer-reviewed journal uniquely positioned to provide investigators with the most recent advances across the breadth of the cellular and molecular neurosciences. The official journal of the American Society for Neurochemistry, ASN NEURO is dedicated to the promotion, support, and facilitation of communication among cellular and molecular neuroscientists of all specializations.