Individualized Homeopathic Medicines in the Treatment of Tinea Corporis: Double-Blind, Randomized, Placebo-Controlled Trial.

IF 1.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Homeopathy Pub Date : 2023-05-01 DOI:10.1055/s-0042-1750799

Bakibillah Laskar, Swapan Paul, Abhijit Chattopadhyay, Avaranjika Karuppusamy, Dharshna Balamurugan, Puja Bhakta, Sourav Das, Siddhartha Pal, Navin Kumar Singh, Munmun Koley, Subhranil Saha

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引用次数: 2

Abstract

Introduction: Tinea corporis (TC; ringworm or dermatophytosis) is a superficial skin infection caused by Microsporum, Epidermophyton and Trichophyton genera of dermatophytes. We compared the effects of individualized homeopathic medicines (IHMs) in fifty-millesimal (LM) potencies against placebo in TC.

Methods: A double-blind, randomized, placebo-controlled, two parallel arms trial was conducted on 62 individuals suffering from TC at the National Institute of Homoeopathy, India. Participants were randomized in a 1:1 ratio to receive either IHMs in LM potencies or identical-looking placebos for a period of 3 months. The primary outcome measure was the number of participants showing complete disappearance of skin lesions after 3 months. Secondary outcomes were a numeric rating scale (NRS) measuring intensity of itching and the Skindex-29 questionnaire (overall, and three sub-scales - degree of symptoms, psychological functioning, emotional status). All were assessed at baseline and every month, up to 3 months. The intention-to-treat sample was analyzed to detect inter-group differences using two-way repeated measures analysis of variance after adjusting for baseline differences.

Results: The primary outcome revealed no improvement in either of the groups (χ ² = 0.012, p = 0.999). Inter-group differences in some of the secondary outcomes favored IHMs against placebo - itching NRS (mean group difference after 3 months: -0.7 (95% confidence interval [CI], -1.1 to -0.4; p = 0.001); Skindex-29 overall (mean group difference after 3 months: 3.2 [95% CI, -0.6 to 7.0; p = 0.009]); Skindex-29 degree of symptoms (mean group difference after 3 months: 0.9 [95% CI, -0.2 to 1.9; p = 0.007]); and Skindex-29 psychological functioning (mean group difference after 3 months: 1.7 [95% CI, 0-3.4; p = 0.002]).

Conclusion: Results were negative on the primary outcome; however, secondary outcomes included some statistically significant results favoring IHMs against placebo after 3 months.

Trial registration: CTRI/2019/11/021999; UTN: U1111-1242-0070.

查看原文本刊更多论文

个体化顺势疗法药物治疗体癣:双盲、随机、安慰剂对照试验。

简介:天癣公司(TC;癣或皮癣)是由小孢子菌、表皮菌属和毛菌属引起的浅表皮肤感染。我们比较了个体化顺势疗法药物(IHMs)与安慰剂在TC中的50千分之一效价的效果。方法:在印度国家顺势疗法研究所对62例TC患者进行双盲、随机、安慰剂对照、双平行臂试验。参与者以1:1的比例随机接受3个月的LM效力的ihm或相同外观的安慰剂。主要结果测量是3个月后皮肤病变完全消失的参与者人数。次要结果是测量瘙痒强度的数字评定量表(NRS)和skinindex -29问卷(总体，以及三个子量表-症状程度，心理功能，情绪状态)。所有患者在基线和每月进行评估，直至3个月。对意向治疗样本进行分析，在调整基线差异后，使用双向重复测量方差分析来检测组间差异。结果:两组的主要结局均无改善(χ 2 = 0.012, p = 0.999)。在一些次要结果上，组间差异更有利于IHMs与安慰剂瘙痒NRS(3个月后平均组间差异:-0.7(95%置信区间[CI]， -1.1至-0.4;p = 0.001);皮肤指数-29总体(3个月后平均组差:3.2 [95% CI， -0.6至7.0;p = 0.009]);皮肤指数-29症状程度(3个月后各组平均差异:0.9 [95% CI， -0.2 ~ 1.9;p = 0.007]);和Skindex-29心理功能(3个月后各组平均差异:1.7 [95% CI, 0-3.4;p = 0.002])。结论:主要结局结果为阴性;然而，3个月后，次要结果包括一些统计学上显著的结果，ihm优于安慰剂。试验报名:CTRI/2019/11/021999;UTN: u1111 - 1242 - 0070。

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来源期刊

Homeopathy 医学-全科医学与补充医学

CiteScore

3.40

自引率

70.60%

发文量

审稿时长

20.1 weeks

期刊介绍： Homeopathy is an international peer-reviewed journal aimed at improving the fundamental understanding and clinical practice of homeopathy by publishing relevant high-quality original research articles, reviews, and case reports. It also promotes commentary and debate on matters of topical interest in homeopathy.