Right Ventricular Strain Analysis By Tissue Tracking Cardiac Magnetic Resonance Imaging In Pediatric Patients With End-Stage Renal Disease.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Thoracic Imaging Pub Date : 2024-01-01 Epub Date: 2023-05-29 DOI:10.1097/RTI.0000000000000716

Ahmed M Tawfik, Donia M Sobh, Basma Gadelhak, Mohamed M Zedan, Hoda M Sobh, Riham Eid, Nashwa Hamdy, Nihal M Batouty

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Abstract

Purpose: To investigate right ventricular (RV) volume and mass by cardiac magnetic resonance (CMR) and the added value of tissue tracking strain analysis as markers of RV dysfunction in pediatric patients with end-stage renal disease (ESRD) and preserved RV ejection fraction.

Materials and methods: Twenty-five children with ESRD and preserved RVEF (>50%) and 10 healthy control children were enrolled. Tissue tracking CMR was used to assess Global Longitudinal, circumferential (GCS), and radial short and long axes (GRS SAX and GRS LAX) RV strains in the patients group compared with controls. Correlations between strain parameters and other CMR parameters and clinical biomarkers were assessed. Binary logistic regression was used to test the independence of cofounders and detect their significance.

Results: RV end-diastolic volume and mass (RVMi) were significantly higher in patients (97.2±19.3 mL/m 2 and 26.6±7gr/m 2 ) than control (71±7.8 mL/m 2 and 11.9±2 gr/m 2 , P values 0.000). All RV global strain parameters were significantly impaired in patients compared with control (all P values <0.05). RV Global Longitudinal was significantly correlated to LVEF (r=-0.416, P =0.039), LVEDVi (r=0.481, P =0.015), LVMi (r=0.562, P =0.004), and systolic blood pressure index (r=0.586, P =0.002). RV GRS (LAX) was significantly correlated to LV GCS (r=-0.462, P =0.020) and LV GRS (SAX) (r=0.454, P =0.023). GRS (SAX) and GCS demonstrated the highest diagnostic accuracy (area under curve: 0.82 and 0.81) to detect strain impairment. Univariate binary logistic regression with patients versus control as dependent variables identified LVMi, RV end-diastolic volume, RVMi, weight, body surface area, RV GCS, RV GRS (LAX), RV GRS (SAX), LV GCS, and LV GRS (SAX) as significantly correlated to patients with ESRD. When adjusted to other cofounders in the multivariable model, only RVMi remained as an independent significant cofounder (Odds ratio:0.395, P =0.046).

Conclusion: RV global strain, volume, and mass by CMR are markers of RV dysfunction in ESRD pediatric patients with preserved RVEF.

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通过组织追踪心脏磁共振成像分析终末期肾病儿科患者的右心室应变

目的：通过心脏磁共振（CMR）研究右心室（RV）容积和质量，以及组织追踪应变分析作为终末期肾病（ESRD）和保留RV射血分数的儿科患者RV功能障碍标志物的附加价值：25 名患有 ESRD 且 RVEF 保留（>50%）的儿童和 10 名健康对照组儿童入组。采用组织追踪 CMR 评估患者组与对照组相比的 RV 全局纵向、周向（GCS）、径向短轴和长轴（GRS SAX 和 GRS LAX）应变。评估了应变参数与其他 CMR 参数和临床生物标记物之间的相关性。采用二元逻辑回归检验共因子的独立性并检测其显著性：结果：患者的 RV 舒张末期容积和质量（RVMi）（97.2±19.3 mL/m 2 和 26.6±7gr/m 2 ）明显高于对照组（71±7.8 mL/m 2 和 11.9±2 gr/m 2 ，P 值 0.000）。与对照组相比，患者的所有 RV 整体应变参数都明显受损（所有 P 值均为结论值）：CMR检测的RV整体应变、容积和质量是RVEF保留的ESRD儿科患者RV功能障碍的标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Thoracic Imaging 医学-核医学

CiteScore

7.10

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Thoracic Imaging (JTI) provides authoritative information on all aspects of the use of imaging techniques in the diagnosis of cardiac and pulmonary diseases. Original articles and analytical reviews published in this timely journal provide the very latest thinking of leading experts concerning the use of chest radiography, computed tomography, magnetic resonance imaging, positron emission tomography, ultrasound, and all other promising imaging techniques in cardiopulmonary radiology. Official Journal of the Society of Thoracic Radiology: Japanese Society of Thoracic Radiology Korean Society of Thoracic Radiology European Society of Thoracic Imaging.