Role of the Osteocyte in Musculoskeletal Disease.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2023-06-01 DOI:10.1007/s11914-023-00788-5

Anika Shimonty, Lynda F Bonewald, Fabrizio Pin

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Abstract

Purpose of the review: The purpose of this review is to summarize the role of the osteocyte in muscle atrophy in cancer patients, sarcopenia, spinal cord injury, Duchenne's muscular dystrophy, and other conditions associated with muscle deterioration.

Recent findings: One type of bone cell, the osteocyte, appears to play a major role in muscle and bone crosstalk, whether physiological or pathological. Osteocytes are cells living within the bone-mineralized matrix. These cells are connected to each other by means of dendrites to create an intricately connected network. The osteocyte network has been shown to respond to different types of stimuli such as mechanical unloading, immobilization, aging, and cancer by producing osteocytes-derived factors. It is now becoming clear that some of these factors including sclerostin, RANKL, TGF-β, and TNF-α have detrimental effects on skeletal muscle. Bone and muscle not only communicate mechanically but also biochemically. Osteocyte-derived factors appear to contribute to the pathogenesis of muscle disease and could be used as a cellular target for new therapeutic approaches.

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骨细胞在肌肉骨骼疾病中的作用。

综述的目的:本综述的目的是总结骨细胞在癌症患者肌肉萎缩、肌肉减少症、脊髓损伤、杜氏肌营养不良症和其他与肌肉退化相关的疾病中的作用。最近的研究发现:一种骨细胞，骨细胞，似乎在肌肉和骨骼的串扰中起主要作用，无论是生理的还是病理的。骨细胞是生活在骨矿化基质中的细胞。这些细胞通过树突相互连接，形成一个错综复杂的连接网络。骨细胞网络已被证明通过产生骨细胞衍生因子来响应不同类型的刺激，如机械卸载、固定、衰老和癌症。现在越来越清楚的是，包括硬化蛋白、RANKL、TGF-β和TNF-α在内的一些因子对骨骼肌有有害影响。骨骼和肌肉不仅在机械上交流，而且在生物化学上交流。骨细胞衍生因子似乎有助于肌肉疾病的发病机制，并可作为新的治疗方法的细胞靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.