Differential expression of the Tmem132 family genes in the developing mouse nervous system

IF 1 4区生物学 Q4 DEVELOPMENTAL BIOLOGY

Gene Expression Patterns Pub Date : 2022-09-01 DOI:10.1016/j.gep.2022.119257

Yuan Wang , Graham Herzig , Cassandra Molano , Aimin Liu

引用次数: 0

Abstract

The family of novel transmembrane proteins (TMEM) 132 have been associated with multiple neurological disorders and cancers in humans, but have hardly been studied in vivo. Here we report the expression patterns of the five Tmem132 genes (a, b, c, d and e) in developing mouse nervous system with RNA in situ hybridization in wholemount embryos and tissue sections. Our results reveal differential and partially overlapping expression of multiple Tmem132 family members in both the central and peripheral nervous system, suggesting potential partial redundancy among them.

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Tmem132家族基因在发育中的小鼠神经系统中的差异表达

新型跨膜蛋白(TMEM) 132家族与人类多种神经系统疾病和癌症有关，但很少在体内进行研究。在这里，我们用RNA原位杂交技术报道了发育中的小鼠神经系统中5个Tmem132基因(a、b、c、d和e)的表达模式。我们的研究结果揭示了多个Tmem132家族成员在中枢和外周神经系统中的差异和部分重叠表达，表明它们之间可能存在部分冗余。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene Expression Patterns 生物-发育生物学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Gene Expression Patterns is devoted to the rapid publication of high quality studies of gene expression in development. Studies using cell culture are also suitable if clearly relevant to development, e.g., analysis of key regulatory genes or of gene sets in the maintenance or differentiation of stem cells. Key areas of interest include: -In-situ studies such as expression patterns of important or interesting genes at all levels, including transcription and protein expression -Temporal studies of large gene sets during development -Transgenic studies to study cell lineage in tissue formation