Circulating leukocyte cell-derived chemotaxin 2 and fibroblast growth factor 21 are negatively associated with cardiorespiratory fitness in healthy volunteers.

IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS
Sundus Malaikah, Scott A Willis, Joseph Henson, Jack A Sargeant, Thomas Yates, Alice E Thackray, Fernanda R Goltz, Matthew J Roberts, Danielle Bernard-Deshong, Guruprasad P Aithal, David J Stensel, James A King
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Abstract

Leukocyte cell-derived chemotaxin-2 (LECT2) and fibroblast growth factor 21 (FGF21) are hepatokines that are regulated by energy balance and mediate insulin sensitivity and glycaemic control. This cross-sectional study examined the independent associations of cardiorespiratory fitness (CRF), moderate-to-vigorous intensity physical activity (MVPA), and sedentary time with circulating LECT2 and FGF21. Data were combined from two previous experimental studies in healthy volunteers (n = 141, male = 60%, mean ± SD age = 37 ± 19 years, body mass index (BMI) = 26.1 ± 6.3 kg·m-2). Sedentary time and MVPA were measured via an ActiGraph GT3X + accelerometer, while magnetic resonance imaging quantified liver fat. CRF was assessed using incremental treadmill tests. Generalized-linear models examined the association of CRF, sedentary time, and MVPA with LECT2 and FGF21 while controlling for key demographic and anthropometric variables. Interaction terms explored the moderating influence of age, sex, BMI, and CRF. In the fully adjusted models, each SD increase in CRF was independently associated with a 24% (95% CI: -37% to -9%, P = 0.003) lower plasma LECT2 concentration and 53% lower FGF21 concentration (95% CI: -73% to -22%, P = 0.004). Each SD increase in MVPA was independently associated with 55% higher FGF21 (95% CI: 12% to 114%, P = 0.006), and this relationship was stronger in those with lower BMI and higher levels of CRF. These findings demonstrate that CRF and wider activity behaviours may independently modulate the circulating concentrations of hepatokines and thereby influence inter-organ cross-talk.

循环白细胞来源的趋化素2和成纤维细胞生长因子21与健康志愿者的心肺功能呈负相关。
白细胞来源的趋化素-2 (LECT2)和成纤维细胞生长因子21 (FGF21)是受能量平衡调节并介导胰岛素敏感性和血糖控制的肝因子。本横断面研究考察了心肺功能(CRF)、中高强度体力活动(MVPA)和久坐时间与循环LECT2和FGF21之间的独立关联。数据来源于之前两项健康志愿者的实验研究(n = 141,男性= 60%,平均±SD年龄= 37±19岁,体重指数(BMI) = 26.1±6.3 kg·m-2)。通过ActiGraph GT3X +加速度计测量久坐时间和MVPA,同时磁共振成像量化肝脏脂肪。采用渐进式跑步机试验评估CRF。广义线性模型检验了CRF、久坐时间和MVPA与LECT2和FGF21之间的关系,同时控制了关键的人口统计学和人体测量变量。相互作用项探讨年龄、性别、BMI和CRF的调节作用。在完全调整后的模型中,CRF每增加一个SD,血浆LECT2浓度降低24% (95% CI: -37%至-9%,P = 0.003)和FGF21浓度降低53% (95% CI: -73%至-22%,P = 0.004)独立相关。MVPA每增加一个SD与FGF21升高55%独立相关(95% CI: 12% ~ 114%, P = 0.006),并且这种关系在BMI较低和CRF水平较高的患者中更强。这些发现表明,CRF和更广泛的活动行为可能独立调节肝因子的循环浓度,从而影响器官间的串扰。
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来源期刊
CiteScore
6.50
自引率
2.90%
发文量
113
审稿时长
4-8 weeks
期刊介绍: Applied Physiology, Nutrition, and Metabolism publishes original research articles, reviews, and commentaries, focussing on the application of physiology, nutrition, and metabolism to the study of human health, physical activity, and fitness. The published research, reviews, and symposia will be of interest to exercise physiologists, physical fitness and exercise rehabilitation specialists, public health and health care professionals, as well as basic and applied physiologists, nutritionists, and biochemists.
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