{"title":"Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity","authors":"","doi":"10.1080/14786419.2023.2218530","DOIUrl":null,"url":null,"abstract":"<div><div><em>Hypoxylon vinosopulvinatum</em> DYR-1-7 is a endophytic fungus isolated from the <em>Cinnamomum cassia</em> Presl and has an inhibitory effect on <em>Lasiodiplodia pseudotheobromae</em>. Three new furanones, hypoxylonone A-C (<strong>1</strong>-<strong>3</strong>), as well as three known compounds (<strong>4</strong>-<strong>6</strong>), were isolated from an EtOAc extract of <em>H. vinosopulvinatum</em> DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of <strong>1</strong>-<strong>3</strong> were elucidated by electronic circular dichroism (ECD) analyses. In the antifungal bioassay, Hypoxylonone B and <strong>C</strong> exhibited strong inhibitory effects on <em>L. pseudotheobromae</em> with IC<sub>50</sub> value at the concentration of 1.01 and 2.40 μg/mL, respectively. Compound <strong>6</strong> showed medium antifungal activity with IC<sub>50</sub> value at the concentration of 10.67 μg/mL on <em>Fusarium oxysporum</em>. Compounds <strong>3</strong> and <strong>4</strong> displayed medium antifungul effects on <em>Candida albicans</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641923017795","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Hypoxylon vinosopulvinatum DYR-1-7 is a endophytic fungus isolated from the Cinnamomum cassia Presl and has an inhibitory effect on Lasiodiplodia pseudotheobromae. Three new furanones, hypoxylonone A-C (1-3), as well as three known compounds (4-6), were isolated from an EtOAc extract of H. vinosopulvinatum DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of 1-3 were elucidated by electronic circular dichroism (ECD) analyses. In the antifungal bioassay, Hypoxylonone B and C exhibited strong inhibitory effects on L. pseudotheobromae with IC50 value at the concentration of 1.01 and 2.40 μg/mL, respectively. Compound 6 showed medium antifungal activity with IC50 value at the concentration of 10.67 μg/mL on Fusarium oxysporum. Compounds 3 and 4 displayed medium antifungul effects on Candida albicans.
期刊介绍:
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.