Association between serum interleukin-6, leptin and insulin in gestational diabetes mellitus - a cross- sectional study.

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2023-02-13 eCollection Date: 2023-06-01 DOI:10.1007/s40200-023-01188-3

Neha Srivastava, Kalpana Singh, Nisha Singh, Abbas Ali Mahdi

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Abstract

Purpose: Gestational diabetes mellitus (GDM) is a state of leptin resistance which develops a vicious cycle of hyperinsulinemia and hyperleptinemia leading to aggravation of an inflammatory situation. This study was done to find out the association between IL-6, leptin and insulin in gestational diabetes among North Indian women.

Method: This cross-sectional study included 100 GDM, 100 non-GDM and 50 non-pregnant women. DIPSI (Diabetes in Pregnancy Study Group India) criteria was used for screening GDM among pregnant women. GDM and non-GDM pregnant women were further categorized into three groups according to the trimester of pregnancy. Serum IL-6, leptin and insulin were measured in all the enrolled women.

Results: Serum IL-6 levels were significantly higher among GDM women as compared to non-GDM and non-pregnant women. Although the mean serum leptin and insulin levels were higher in GDM, but the difference was not statistically significant. When GDM and non-GDM women were categorized into three trimester, serum leptin levels were found to be significantly higher in 3rd trimester (p < 0.002) and IL-6 in 1st trimester (p < 0.017) among GDM women. No correlation was found between serum IL-6, leptin and insulin in GDM.

Conclusion: Absence of any significant association between leptin and IL-6 signifies that leptin may not be associated with inflammation in gestational diabetes. However, IL-6 may serve as an early marker for screening glucose intolerance during pregnancy.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-023-01188-3.

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妊娠期糖尿病患者血清白细胞介素-6、瘦素和胰岛素的相关性研究。

目的：妊娠期糖尿病（GDM）是一种瘦素抵抗状态，它会形成高胰岛素血症和高瘦素血症的恶性循环，导致炎症情况恶化。本研究旨在了解IL-6、瘦素和胰岛素在北印度女性妊娠期糖尿病中的相关性。方法：这项横断面研究包括100名GDM、100名非GDM和50名非孕妇。DIPSI（印度妊娠期糖尿病研究组）标准用于筛查孕妇GDM。GDM和非GDM孕妇根据妊娠期进一步分为三组。测量所有入选女性的血清IL-6、瘦素和胰岛素。结果：GDM妇女血清IL-6水平显著高于非GDM和非妊娠妇女。尽管GDM患者的平均血清瘦素和胰岛素水平较高，但差异无统计学意义。当GDM和非GDM妇女被分为三个妊娠期时，发现血清瘦素水平在妊娠晚期显著升高（p 结论：瘦素和IL-6之间没有任何显著的相关性，这表明瘦素可能与妊娠期糖尿病的炎症无关。然而，IL-6可能是筛查妊娠期葡萄糖不耐受的早期标志物。补充信息：在线版本包含补充材料，可访问10.1007/s40200-023-01188-3。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.