Polymer based Gels: Recent and Future Applications in Drug Delivery Field.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2023-01-01 DOI:10.2174/1567201819666220907124040

Panoraia I Siafaka, Evren Atlıhan Gündoğdu, Emre Sefik Cağlar, Emre Özgenç, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Neslihan Üstündağ Okur

{"title":"Polymer based Gels: Recent and Future Applications in Drug Delivery Field.","authors":"Panoraia I Siafaka, Evren Atlıhan Gündoğdu, Emre Sefik Cağlar, Emre Özgenç, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Neslihan Üstündağ Okur","doi":"10.2174/1567201819666220907124040","DOIUrl":null,"url":null,"abstract":"Background: Currently, there is ongoing research in the pharmaceutical technology field to develop innovative drug delivery systems with improved therapeutic efficacy.Objectives: Although there is a high need for new drug molecules, most scientists focus on the advancement of novel pharmaceutical formulations since the present excipients lack important properties such as low release rate leading to repeated dosing. Aside from this, pharmaceutical technologists aim to develop drug formulations that can target specific organs and tissues, lowering the possibility of adverse effects.Methods: This review aims to cover the different polymer-based gel types, the development and characterization methods, as well as applications thereof. Finally, the recent advancements and future perspectives focusing on radiolabeled gels will be addressed.Results: In the last decades, polymer based pharmaceutical gels have shown attractive properties and therefore have raised the attention of pharmaceutical scientists. Gels are either chemically or physically cross-linked networks that can absorb fluids such as water (hydrogels), oil (organogels) and even air(aerogels). A variety of polymers, either synthetic or natural, have been employed as components for the gels. Stimuli-responsive gels based on stimuli-sensitive polymers are among the most studied gel class of last years.Conclusion: The use of polymer-based gels as drug delivery systems would be beneficial for targeting numerous diseases.","PeriodicalId":10842,"journal":{"name":"Current drug delivery","volume":"20 9","pages":"1288-1313"},"PeriodicalIF":2.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current drug delivery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/1567201819666220907124040","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 3

Abstract

Background: Currently, there is ongoing research in the pharmaceutical technology field to develop innovative drug delivery systems with improved therapeutic efficacy.

Objectives: Although there is a high need for new drug molecules, most scientists focus on the advancement of novel pharmaceutical formulations since the present excipients lack important properties such as low release rate leading to repeated dosing. Aside from this, pharmaceutical technologists aim to develop drug formulations that can target specific organs and tissues, lowering the possibility of adverse effects.

Methods: This review aims to cover the different polymer-based gel types, the development and characterization methods, as well as applications thereof. Finally, the recent advancements and future perspectives focusing on radiolabeled gels will be addressed.

Results: In the last decades, polymer based pharmaceutical gels have shown attractive properties and therefore have raised the attention of pharmaceutical scientists. Gels are either chemically or physically cross-linked networks that can absorb fluids such as water (hydrogels), oil (organogels) and even air(aerogels). A variety of polymers, either synthetic or natural, have been employed as components for the gels. Stimuli-responsive gels based on stimuli-sensitive polymers are among the most studied gel class of last years.

Conclusion: The use of polymer-based gels as drug delivery systems would be beneficial for targeting numerous diseases.

查看原文本刊更多论文

聚合物基凝胶:在药物输送领域的最新和未来应用。

背景:目前，制药技术领域正在进行开发具有更高治疗效果的创新给药系统的研究。目的:虽然对新药物分子的需求很大，但由于目前的赋形剂缺乏重要的特性，如释放率低导致重复给药，大多数科学家关注的是新药物配方的进步。除此之外，制药技术人员的目标是开发能够针对特定器官和组织的药物配方，降低不良反应的可能性。方法:综述了聚合物基凝胶的不同类型、发展、表征方法及其应用。最后，将讨论放射性标记凝胶的最新进展和未来展望。结果:在过去的几十年里，聚合物基药物凝胶显示出诱人的性能，因此引起了药理学家的注意。凝胶是一种化学上或物理上的交联网络，可以吸收水(水凝胶)、油(有机凝胶)甚至空气(气凝胶)等流体。各种聚合物，无论是合成的还是天然的，都被用作凝胶的组成部分。基于刺激敏感聚合物的刺激反应凝胶是近年来研究最多的凝胶类之一。结论:聚合物基凝胶作为药物传递系统将有利于治疗多种疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.