Docetaxel-induced Flagellate Erythema - Case Report and Brief Review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.2174/1574886317666220613155550

Jerbi Asma, Kastalli Sarrah, Charfi Ons, Dhaghfous Riadh, El Aidli Sihem

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引用次数: 0

Abstract

Introduction: Flagellate erythema is a distinctive morphologic reaction pattern recognized by whiplash-like pruritic erythematous eruption. It is usually encountered in patients receiving bleomycin. Only one case of docetaxel-induced flagellate erythema is reported in the literature.

Case report: Herein, we report a rare case of docetaxel-induced flagellate erythema in a 53 years old woman with no particular medical history treated with docetaxel for metastatic adenocarcinoma of her right breast. Seven days after the third course, she developed multiple lineal and parallel pruritic erythematous streaks mainly on her chest and abdomen. The cutaneous erythema disappeared gradually over 10 days, leaving hyper-pigmented post-inflammatory linear scars lasting two weeks. The same reaction reappeared after the fourth and the fifth docetaxel course.

Conclusion: Flagellate erythema has been reported as an adverse drug reaction secondary to several antineoplastic molecules, including docetaxel. Further studies are needed to discover its underlying mechanisms in order to figure out better treatment plans and prevention.

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多西他赛致鞭毛性红斑1例报告及简要回顾。

简介:鞭毛状红斑是一种独特的形态反应模式，可识别为鞭状样瘙痒性红斑疹。它通常在接受博来霉素治疗的患者中出现。文献中仅报道一例多西他赛诱导的鞭毛状红斑。病例报告:在此，我们报告一例罕见的多西他赛诱导的鞭毛状红斑，患者为53岁女性，无特殊病史，因右乳转移性腺癌接受多西他赛治疗。第三疗程后第7天，患者出现多条状平行瘙痒性红斑，主要见于胸部和腹部。皮肤红斑在10天内逐渐消失，留下持续两周的色素沉着的炎症后线状疤痕。多西紫杉醇第4、5个疗程后再次出现相同反应。结论:鞭毛状红斑已被报道为包括多西他赛在内的几种抗肿瘤分子继发的药物不良反应。为了找到更好的治疗方案和预防措施，需要进一步的研究来发现其潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.