Shuai Jiang, Shuai Geng, Xinyue Gao, Tong Liu, Xinyu Luo, Nan Wang, Ning Shi, Mei Dong
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引用次数: 0
Abstract
Objective: Clinical studies have shown that trastuzumab combined with pertuzumab (dual-targeted drug therapy) can significantly improve the treatment status and prognosis of HER-2 positive breast cancer patients through double targeting of HER-2. This study systematically evaluated the efficacy and safety of trastuzumab combined with pertuzumab in the treatment of HER-2 positive breast cancer.Method: We search relevant databases and collect RCTs on the treatment of HER-2 positive breast cancer with dual-targeted treatment. Meta-analysis was performed using Revman5.4 software.Results: A total of 10 studies for 8553 patients were included. Meta-analysis showed that, in terms of efficacy, overall survival (OS) (HR = 1.40, 95%CI = 1.29-1.53, p < 0.00001) and progression-free survival (PFS) (HR = 1.36, 95%CI = 1.28-1.46, p < 0.00001) in dual-targeted drug therapy were better than which in the single-targeted drug group. In terms of safety, the highest incidence (Relative risk, RR) of Adverse reactions was Infections and infestations (RR = 1.48, 95%CI = 1.24-1.77, p < 0.0001) follow by Nervous system disorders (RR = 1.29, 95%CI = 1.12-1.50, p = 0.0006), Gastrointestinal disorders (RR = 1.25, 95%CI = 1.18-1.32, p < 0.0001), Respiratory, thoracic, and mediastinal disorders (RR = 1.21, 95%CI = 1.01-1.46, p = 0.04), Skin and subcutaneous tissue disorders (RR = 1.14, 95%CI = 1.06-1.22, p = 0.0002) and General disorders (RR = 1.14, 95%CI = 1.04-1.25, p = 0.004) in dual-targeted drug therapy group. The incidence of Blood system disorder (RR = 0.94, 95%CI = 0.84-1.06, p = 0.32) and Liver dysfunction (RR = 0.80, 95%CI = 0.66-0.98, p = 0.03) was lower than that of the single targeted drug group.Conclusion: Dual-targeted treatment for HER-2-positive breast cancer can prolong the OS, PFS and improve the quality of patients' life. Meanwhile, it also brings a higher medication risk, which requires a rational selection of drug symptomatic interventions.
目的：临床研究表明，曲妥珠单抗联合帕妥珠单抗（双靶向药物治疗）可通过HER-2的双靶向治疗，显著改善HER-2阳性乳腺癌症患者的治疗状况和预后。本研究系统评价了曲妥珠单抗联合帕妥珠单抗治疗HER-2阳性乳腺癌症的疗效和安全性。方法：检索相关数据库，收集双靶向治疗HER-2阳性乳腺癌症的随机对照试验。使用Revman5.4软件进行荟萃分析。结果：共纳入10项研究，涉及8553名患者。荟萃分析显示，就疗效而言，总生存期（OS）（HR=1.40，95%CI=1.29-1.53，p p p p = 0.0006），胃肠道疾病（RR=1.25，95%CI=1.18-1.32，p p = 0.04），皮肤和皮下组织疾病（RR=1.14，95%CI=1.06-1.22，p = 0.0002）和一般性疾病（RR=1.14，95%CI=1.04-1.25，p = 0.004）。血液系统疾病的发生率（RR=0.94，95%CI=0.84-1.06，p = 0.32）和肝功能障碍（RR=0.80，95%CI=0.66-0.98，p = 0.03）低于单一靶向药物组。结论：HER-2阳性乳腺癌症双靶向治疗可延长OS、PFS，提高患者的生活质量。同时，它也带来了更高的用药风险，这需要合理选择药物症状干预措施。
期刊介绍：
The journal Immunopharmacology and Immunotoxicology is devoted to pre-clinical and clinical drug discovery and development targeting the immune system. Research related to the immunoregulatory effects of various compounds, including small-molecule drugs and biologics, on immunocompetent cells and immune responses, as well as the immunotoxicity exerted by xenobiotics and drugs. Only research that describe the mechanisms of specific compounds (not extracts) is of interest to the journal.
The journal will prioritise preclinical and clinical studies on immunotherapy of disorders such as chronic inflammation, allergy, autoimmunity, cancer etc. The effects of small-drugs, vaccines and biologics against central immunological targets as well as cell-based therapy, including dendritic cell therapy, T cell adoptive transfer and stem cell therapy, are topics of particular interest. Publications pointing towards potential new drug targets within the immune system or novel technology for immunopharmacological drug development are also welcome.
With an immunoscience focus on drug development, immunotherapy and toxicology, the journal will cover areas such as infection, allergy, inflammation, tumor immunology, degenerative disorders, immunodeficiencies, neurology, atherosclerosis and more.
Immunopharmacology and Immunotoxicology will accept original manuscripts, brief communications, commentaries, mini-reviews, reviews, clinical trials and clinical cases, on the condition that the results reported are based on original, clinical, or basic research that has not been published elsewhere in any journal in any language (except in abstract form relating to paper communicated to scientific meetings and symposiums).
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