Conventional and Advanced MRI Techniques in the Evaluation of Primary CNS Lymphoma

IF 1.5 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Seminars in Ultrasound Ct and Mri Pub Date : 2023-06-01 DOI:10.1053/j.sult.2023.02.003

Raffaella Capasso PhD, MD , Alberto Negro PhD, MD , Camilla Russo PhD , Fabio Zeccolini MD , Gianluca Muto , Ferdinando Caranci Prof MD , Antonio Pinto PhD, MD

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引用次数: 0

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin's lymphoma that accounts for 1%-5% of all central nervous system tumors. Contrast-enhanced MR is the imaging technique of choice. PCNLs have a predilection for the periventricular and superficial regions, often abutting the ventricular or meningeal surfaces. Although PCNLs may have characteristic imaging features on conventional MRI, none of these will unequivocally differentiate PCNSLs from other brain lesions. Diffusion restriction, relative hypoperfusion, increased choline/creatinine, decrease of N-acetyl aspartate (NAA) peak as well as the presence of lactate and lipid peaks are consistent advanced imaging findings in CNS lymphoma that may help in the differentiation of Primary central nervous system lymphomas (PCNSLs) from other malignancies. Furthermore, advanced imaging techniques will presumably play an important role in the planning of new targeted therapies, for prognostication, and for the monitoring of treatment response in the future.

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常规和先进的MRI技术对原发性中枢神经系统淋巴瘤的评价

原发性中枢神经系统淋巴瘤（PCNSL）是一种罕见的结外非霍奇金淋巴瘤，占所有中枢神经系统肿瘤的1%-5%。对比度增强MR是一种选择的成像技术。PCNL倾向于心室周围和浅表区域，通常与心室或脑膜表面邻接。尽管PCNL在常规MRI上可能具有特征性的成像特征，但这些都不能明确区分PCNSL和其他脑损伤。扩散限制、相对低灌注、胆碱/肌酸酐增加、N-乙酰天冬氨酸（NAA）峰降低以及乳酸和脂质峰的存在是中枢神经系统淋巴瘤的一致高级成像结果，可能有助于区分原发性中枢神经系统淋巴瘤（PCNSL）和其他恶性肿瘤。此外，先进的成像技术可能在规划新的靶向治疗、预测和监测未来的治疗反应方面发挥重要作用。

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来源期刊

Seminars in Ultrasound Ct and Mri 医学-核医学

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Ultrasound, CT and MRI is directed to all physicians involved in the performance and interpretation of ultrasound, computed tomography, and magnetic resonance imaging procedures. It is a timely source for the publication of new concepts and research findings directly applicable to day-to-day clinical practice. The articles describe the performance of various procedures together with the authors'' approach to problems of interpretation.