The effects of cream-based Triticum vulgare with and without therapeutic ultrasound on excisional wound healing in diabetic rats.

IF 1.6 4区医学 Q3 OPHTHALMOLOGY

Cutaneous and Ocular Toxicology Pub Date : 2023-06-01 DOI:10.1080/15569527.2023.2201833

Ayşe Gölgeli Bedir, Latif Emrah Yanmaz

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引用次数: 0

Abstract

Purpose: The purpose of the current study was to evaluate the effect of Triticum vulgare (TVE) alone or combined with therapeutic ultrasound (TUS) on wound healing in a diabetic rat model.

Materials and methods: A total of 72 male Wistar rats were randomly divided into four groups: Group Control, wounded rats without treatment; Group TUS, wounded rats with TUS application; Group TVE, wounded rats treated with TVE; and Group TVE + TUS, wounded rats treated with TVE + TUS. Wound healing was assessed using wound area calculation and thermographic, biochemical, histopathologic, immunohistochemical, and immunofluorescence analyses on post-wounding days 7, 14, and 21.

Results: On day 21, the wound surface area was significantly decreased in Group TVE + TUS (0.18 ± 0.07 cm²) compared to the other groups (p < 0.001). A significant increase in wound area temperature was recorded on days 7, 14, and 21 in all groups compared to day 0 (p < 0.001). On day 21, Group TVE + TUS (35.4 ± 0.2 °C) had the most significantly highest wound area temperature compared to the other groups (p < 0.001). The highest histopathological scores were recorded in Group TVE + TUS on days 7, 14, and 21 (p = 0.04). The highest vascular endothelial growth factor expression was observed in Group TVE + TUS (82.53 ± 1.98) on day 7 (p = 0.03).

Conclusion: In conclusion, treatment with a combination of TVE and TUS effectively enhanced wound healing in diabetic rats compared with other treatment groups.

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乳基普通小麦加与不加超声治疗对糖尿病大鼠手术创面愈合的影响。

目的:评价普通小麦(Triticum vulgare, TVE)单独或联合治疗性超声(therapeutic ultrasound, TUS)对糖尿病大鼠模型创面愈合的影响。材料与方法:将72只雄性Wistar大鼠随机分为4组:对照组为未治疗的损伤大鼠;TUS组，应用TUS的损伤大鼠;TVE组，TVE治疗的损伤大鼠;TVE + TUS组为TVE + TUS治疗的损伤大鼠。伤口愈合评估采用伤口面积计算和热成像、生化、组织病理学、免疫组织化学和免疫荧光分析在伤口后7、14和21天。结果:第21天，TVE + TUS组创面面积较其他组明显减少(0.18±0.07 cm2) (p p p p = 0.04)。TVE + TUS组血管内皮生长因子表达量在第7天最高(82.53±1.98)(p = 0.03)。结论:与其他治疗组相比，TVE与TUS联合治疗可有效促进糖尿病大鼠创面愈合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cutaneous and Ocular Toxicology 医学-毒理学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.